Older adults increasingly have HPV+ oropharyngeal cancers

June 13, 2018

(HealthDay)—Human papillomavirus (HPV)-positive oropharyngeal cancers are increasing among older adults, according to a study published online April 30 in Cancer.

Melina J. Windon, M.D., from Johns Hopkins University in Baltimore, and colleagues retrospectively studied 239 cases of oropharyngeal squamous cell carcinoma (OPSCC) diagnosed at two National Comprehensive Cancer Network-designated centers (1995 to 2013). P16 immunohistochemistry and in situ hybridization (ISH) for HPV-16, high-risk DNA, and/or E6/E7 RNA were performed. Age at diagnosis was compared by p16 and ISH tumor status.

The researchers found that 60 percent of patients were p16-positive. Over the study period the median age increased among p16-positive patients (P trend = 0.01) from 53 to 58 years, but not among p16-negative patients (P trend = 0.71). The proportion of OPSCCs that were p16-positive increased among ≥65 years old, from 41 percent during 1995 to 2000 to 75 percent during 2007 to 2013 (P trend = 0.04). Regardless of age, a p16-positive tumor status improved overall survival.

"The at diagnosis for HPV-related OPSCC is increasing as the proportion of OPSCCs caused by HPV rises among ," the authors write.

One author is on the scientific advisory boards of Medtronic and Olympus and is a consultant for Ziteo.

Explore further: HPV leaves its mark in oropharyngeal squamous cell carcinoma

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

HPV leaves its mark in oropharyngeal squamous cell carcinoma

May 1, 2013
Oropharyngeal squamous cell carcinoma (OPSCC) is a form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx.

Rise in oropharyngeal cancer incidence not solely driven by HPV in United Kingdom

October 11, 2016
The rise in incidence of oropharyngeal squamous cell carcinoma in the United Kingdom from 2002 to 2011 was not solely attributable to a rise in incidence of human papillomavirus (HPV)-positive disease because the proportion ...

Better prognosis with surgery for HPV-linked oropharyngeal SCC

July 18, 2017
(HealthDay)—Patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) have higher five-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone, according ...

Study questions rise of head and neck cancers in the UK

October 10, 2016
In the first study of its kind researchers from the University of Liverpool's Institute of Translational Medicine have examined the possible reasons for the rapid increase in incidence of particular head and neck cancers ...

Periodontitis linked to HPV-positive head, neck tumors

June 20, 2012
(HealthDay) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published ...

Most HPV+ OPSCC recurrence, toxicity events occur early

February 15, 2016
(HealthDay)—For patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC), most of the disease recurrence and late toxicity events after treatment occur within six months, according ...

Recommended for you

Study suggests well-known growth suppressor actually fuels lethal brain cancers

June 18, 2018
Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. But they also say the current lack of a drug that hits the molecular target keeps it ...

Targeting the engine room of the cancer cell

June 18, 2018
Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug ...

Genomics offers new treatment options for infants with range of soft tissue tumors

June 18, 2018
The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators. Whole genome sequencing of tumours revealed ...

Researchers create novel combination as potential therapy for high-risk neuroblastoma

June 18, 2018
Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for ...

Standard myelofibrosis drug can awaken 'dormant' lymphoma

June 18, 2018
Most patients with myelofibrosis, a rare chronic disorder of the haematopoietic cells of the bone marrow, benefit from drugs from the JAK2 inhibitor class: symptoms are relieved, survival extended and general quality-of-life ...

Breast cancer researcher warns against online genetic tests

June 18, 2018
We have never been so fascinated by the secrets inside our cells.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.