Toothpaste and hand wash may contribute to antibiotic resistance

June 19, 2018, University of Queensland
Toothpaste and hand wash may contribute to antibiotic resistance
Dr Jianhua Guo (left) and PhD student Ji Lu conducting experiments using triclosan. Credit: University of Queensland

A common ingredient in toothpaste and hand wash could be contributing to antibiotic resistance, according to University of Queensland research.

A study led by Dr. Jianhua Guo from UQ's Advanced Water Management Centre focused on triclosan, a compound used in more than 2000 .

Dr. Guo said while it was well-known the overuse and misuse of could create 'superbugs', researchers were unaware that other chemicals could also induce until now.

"Wastewater from residential areas has similar or even higher levels of antibiotic resistant bacteria and compared to hospitals, where you would expect greater antibiotic concentrations," he said.

"We then wondered whether non-antibiotic, antimicrobial (NAAM) chemicals such as triclosan can directly induce antibiotic resistance," Dr. Guo said.

"These chemicals are used in much larger quantities at an everyday level, so you end up with high residual levels in the wider environment, which can induce multi-drug resistance.

"This discovery provides strong evidence that the triclosan found in personal care products that we use daily is accelerating the spread of antibiotic resistance."

Credit: University of Queensland

Advanced Water Management Centre Director, Professor Zhiguo Yuan, said the discovery should be a wake-up call to re-evaluate the potential impact of such chemicals.

"While the US Food and Drug Administration (FDA) has banned the use of triclosan in antibacterial soap, the previous lack of unequivocal evidence prevented such a policy being adopted in other countries," Professor Yuan said.

Antimicrobial has become a major threat to public health globally with approximately 700,000 people a year dying from antimicrobial-resistant infections.

The Review on Antimicrobial Resistance report predicted this will reach 10 million deaths a year by 2050 if no action is taken now.

The study was published in Environment International.

Explore further: Ban on triclosan shows need for new chemicals to demonstrate efficacy and safety

More information: Ji Lu et al. Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation, Environment International (2018). DOI: 10.1016/j.envint.2018.06.004

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