Urinary markers predict bone problems after hip replacement

June 6, 2018, Wiley

In a study published in the Journal of Orthopaedic Research, investigators have identified urinary markers that differentiate total hip replacement patients who eventually develop bone tissue destruction, or osteolysis, from patients who do not.

For the study, researchers used a repository of 24-hour urine samples collected prior to surgery and annually thereafter in 26 , 16 who developed osteolysis and 10 who did not.

The levels of certain markers helped the investigators identify patients at risk for osteolysis long before the emergence of signs through imaging tests—in some cases 6 years before a diagnosis was made. Although single markers showed moderate accuracy, the combination of α-CTX, a bone resorption marker, and IL-6, an inflammatory marker, led to high accuracy in the differentiation of patients who eventually developed osteolysis from those with no signs of osteolysis.

"We are hopeful that early biomarkers for implant loosening will alert surgeons to be especially vigilant in their follow-up of at-risk patients and may eventually lead to treatments delaying or avoiding the need for revision surgery," said senior author Dr. D. Rick Sumner, of Rush University Medical Center, in Chicago. "Perhaps even more intriguing is that the two biomarkers we identified also differed before among patients who eventually developed peri-implant osteolysis and those who did not, supporting the concept that other researchers have proposed of for loosening."

Explore further: HRT cuts risk of repeat knee/hip replacement surgery by 40 percent

More information: Ryan D. Ross et al, Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis, Journal of Orthopaedic Research (2018). DOI: 10.1002/jor.24044

Related Stories

HRT cuts risk of repeat knee/hip replacement surgery by 40 percent

January 22, 2014
Hormone replacement therapy (HRT) taken regularly for six months after a knee or hip replacement seems to cut the risk of repeat surgery by around 40%, indicates a large population based study published online in the Annals ...

Cementless hip implants are durable for at least 20 years

May 1, 2009
Despite the common perception that total hip replacements last about 10 years, researchers at Rush University Medical Center have found that the devices are extremely durable, even 20 years after surgery.

'Dual mobility' hip replacement reduces risk of dislocation

March 6, 2018
More than 330,000 total hip replacements are performed in the United States each year. Overall, it is a highly successful procedure. However, as with all surgeries, a risk for complications exists.

Lasting benefit for rotating-Platform knee arthroplasty

April 25, 2012
(HealthDay) -- After at least 10 years of follow-up, total knee replacement using a second-generation, cemented, rotating-platform, posterior-stabilized total knee prosthesis offers excellent and durable clinical and radiologic ...

Common bone drug may extend life of replacement joints

December 7, 2011
People who take bisphosphonates after joint replacement surgery are less likely to need a repeat operation, finds a new study published in the British Medical Journal today.

Study shows drug effective in treating, preventing breast cancer

November 1, 2007
A new study of an estrogen-derived drug shows promise as a treatment for breast cancer and breast cancer metastases to bone.

Recommended for you

Surprise finding—for very sick elderly, lighter sedation won't drop risk of postoperative delirium, study suggests

August 13, 2018
Johns Hopkins Medicine researchers say a study designed to see if reducing the amount of anesthesia reduces the risk of postoperative delirium in older patients surprisingly found that lighter sedation failed to do so in ...

Kidney transplant chains more effective in saving lives

August 9, 2018
New research from the UBC Sauder School of the Business has found that transplant societies which prioritize kidney transplant chains over kidney exchanges can increase the total number of transplants, thereby saving more ...

Surgical mesh implants may cause autoimmune disorders

July 31, 2018
Surgical mesh implants, often used for hernia or gynecological repair, may be the reason so many patients report symptoms of an autoimmune disorder, according to a University of Alberta rheumatologist.

Surgeons discuss options when the risks of surgery may be too high

July 27, 2018
In an essay published July 26 in the New England Journal of Medicine, Ira Leeds, M.D., research fellow, and David Efron, M.D., professor of surgery, both of the Johns Hopkins University School of Medicine, along with their ...

Blood plasma during emergency air transport saves lives

July 25, 2018
Two units of plasma given in a medical helicopter on the way to the hospital could increase the odds of survival by 10 percent for traumatically injured patients with severe bleeding, according to the results of a national ...

The dark side of antibiotic ciprofloxacin

July 25, 2018
The use of ciprofloxacin and other antibiotics of the class of fluoroquinolones may be associated with disruption of the normal functions of connective tissue, including tendon rupture, tendonitis and retinal detachment. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.