High-risk APOL1 not tied to CVD, stroke in older black women

July 9, 2018

(HealthDay)—For postmenopausal African-American women, high-risk APOL1 genotype seems not to be associated with coronary heart disease, stroke, or mortality, according to a study published online July 3 in JAMA Cardiology.

Nora Fransceschini, M.D., M.P.H., from the University of North Carolina in Chapel Hill, and colleagues used data from the Women's Health Initiative to examine whether high-risk APOL1 genotypes are associated with cardiovascular disease and stroke in postmenopausal African-American women. APOL1 variants were genotyped or imputed from whole-exome sequencing.

The researchers found that high-risk APOL1 carriers had increased prevalence of hypertension, use of cholesterol-lowering medications, and reduced estimated glomerular filtration rate (eGFR). Carriers of high-risk APOL1 variants had increased incidence of hospitalized heart failure with preserved ejection fraction (HFpEF) compared with low-risk carriers after a mean of 11 years; no differences were seen for other outcomes. A significantly increased hazard of hospitalized HFpEF was seen among carriers of high-risk versus low-risk APOL1 variants in adjusted models (hazard ratio, 1.58; 95 percent confidence interval, 1.03 to 2.41). After adjustment for baseline eGFR, the correlation with HFpEF was attenuated and no longer significant (hazard ratio, 1.5; 95 percent confidence interval, 0.98 to 2.3).

"These findings do not support an association of high-risk APOL1 genotypes with , stroke, or mortality in postmenopausal African-American women," the authors write.

Explore further: Gene variants in organ donors linked to shorter survival of transplanted kidneys

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Gene variants in organ donors linked to shorter survival of transplanted kidneys

November 13, 2014
Transplanted kidneys may not function long-term if they come from donors with variants in a particular gene, according to a study that will be presented at ASN Kidney Week 2014 November 11-16 at the Pennsylvania Convention ...

Blacks face a higher risk of kidney failure than whites, regardless of genetics

March 10, 2016
New research investigates the ties between certain genetic variants and kidney disease in African Americans. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest ...

Abdominal obesity linked to all-cause mortality in HFpEF

November 28, 2017
(HealthDay)—For patients with heart failure with preserved ejection fraction (HFpEF), abdominal obesity is associated with increased risk of all-cause mortality, according to a study published in the Dec. 5 issue of the ...

Rapid testing for gene variants in kidney donors may optimize transplant outcomes

March 24, 2015
Kidney transplantation outcomes from deceased African-American donors may improve through rapid testing for apolipoprotein L1 gene (APOL1) renal risk variants at the time of organ recovery, according to a new study led by ...

More rapid decline in kidney function for diagnosed diabetes

June 7, 2018
(HealthDay)—Individuals with diagnosed diabetes have more rapid kidney function decline than those without diabetes, according to a study published online June 1 in Diabetes Care.

Genetics contribute to increased risk for end-stage renal disease for African Americans with chronic kidney disease

November 26, 2013
In the United States, African Americans have approximately twice the risk of end-stage renal disease compared to white Americans, despite a similar prevalence in earlier stages of chronic kidney disease. A large study co-authored ...

Recommended for you

'Good cholesterol' may not always be good

July 19, 2018
Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL) - also known as 'good cholesterol' - according to a study led by researchers in the University of Pittsburgh Graduate ...

Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive

July 18, 2018
A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive—but almost doubles the risk of severe brain damage for survivors of cardiac ...

Omega 3 supplements have little or no heart or vascular health benefit: review

July 17, 2018
New evidence published today shows there is little or no effect of omega 3 supplements on our risk of experiencing heart disease, stroke or death.

Researchers discover new genes associated with heart function

July 17, 2018
A new study from an international research team, led by Dr. Yalda Jamshidi at St George's, University of London, has identified new genes associated with heart function and development.

Southern diet could be deadly for people with heart disease

July 12, 2018
People with a history of heart disease who eat a traditional Southern diet are more likely to die than those who follow a Mediterranean dietary pattern, according to new research.

Late-life high blood pressure may harm the brain, study says

July 11, 2018
Decades ago, hundreds of nuns and priests made an extraordinary decision: They agreed to donate their brains upon death to science, hoping to help solve mysteries about Alzheimer's and other diseases. Now, a study that used ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.