High-risk APOL1 not tied to CVD, stroke in older black women
Nora Fransceschini, M.D., M.P.H., from the University of North Carolina in Chapel Hill, and colleagues used data from the Women's Health Initiative to examine whether high-risk APOL1 genotypes are associated with cardiovascular disease and stroke in postmenopausal African-American women. APOL1 variants were genotyped or imputed from whole-exome sequencing.
The researchers found that high-risk APOL1 variant carriers had increased prevalence of hypertension, use of cholesterol-lowering medications, and reduced estimated glomerular filtration rate (eGFR). Carriers of high-risk APOL1 variants had increased incidence of hospitalized heart failure with preserved ejection fraction (HFpEF) compared with low-risk carriers after a mean of 11 years; no differences were seen for other outcomes. A significantly increased hazard of hospitalized HFpEF was seen among carriers of high-risk versus low-risk APOL1 variants in adjusted models (hazard ratio, 1.58; 95 percent confidence interval, 1.03 to 2.41). After adjustment for baseline eGFR, the correlation with HFpEF was attenuated and no longer significant (hazard ratio, 1.5; 95 percent confidence interval, 0.98 to 2.3).
"These findings do not support an association of high-risk APOL1 genotypes with coronary heart disease, stroke, or mortality in postmenopausal African-American women," the authors write.
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