Nutrient supplement bar improves lung function in asthmatic adolescents

July 19, 2018, Federation of American Societies for Experimental Biology

A small pilot clinical trial published in The FASEB Journal shows that targeted nutrient therapy can improve lung function in obese individuals with asthma without requiring weight loss. Specifically, the study demonstrated that eating two CHORI-Bars (patent-pending supplement bars designed to fill nutritional gaps in poor diets) daily for eight weeks improved lung function in obese adolescents with a form of asthma that is resistant to usual treatments. With a sample size of 56 participants, these findings are provocative and point to the need for larger trials.

"Asthma is common and can be difficult to treat in , who tend to have very poor diets," stated Bruce Ames, Ph.D., senior scientist at UCSF Benioff Children's Hospital Oakland Research Institute (CHORI), who with his colleague Mark Shigenaga, Ph.D., an expert in gut health, originated the idea for the CHORI-Bar. The bar was developed along with a research group at the USDA's Healthy Processed Foods Research Unit.

"It can be difficult for many individuals to adhere to a strict and completely nutritious diet. This study shows that targeted nutritional interventions such as the CHORI-Bar can improve lung function without requiring a complete change in dietary habits," stated Joyce McCann, Ph.D., director of the CHORI-Bar project.

To conduct the clinical trial, the nutritional scientists collaborated with pediatric lung specialists Mustafa Bseikri, MD, Edward Fong, MD, and Karen Hardy, MD. The ability of the bar to improve asthma and quality of life was tested in two groups of obese adolescents with poorly controlled asthma at UCSF Benioff Children's Hospital Oakland. Both groups (totaling 56 participants) attended eight weekly classes that emphasized the importance of healthy eating and exercise, though participants were not required to change their diets. One of the groups also ate two CHORI-Bars each day. The research team measured participants' lung function and other indicators of metabolic health at the beginning and end of the study. Improvement in occurred only in participants who ate the bars.

The study also found that improved only occurred in individuals with a low level of chronic inflammation. The role of chronic inflammation in blunting the positive effects of CHORI-Bar consumption in obese participants was also observed in a 2015 study led by McCann in obese adults, and is a topic for further study.

The development of the CHORI-Bar is grounded in the Triage Theory proposed by Ames in 2006. The theory states that when an essential nutrient is modestly deficient, the body directs the nutrient's limited supply to essential short-term functions, at the expense of those preventing long-term insidious damage, which leads to diseases of aging such as cancer and heart disease. The theory predicts that even a modestly inadequate intake of essential vitamins and minerals can have an adverse effect on bodily functions needed for a long and healthy life.

"This is a tremendous insight, led by a world pioneer in metabolism," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.

Explore further: Clinical studies show 'CHORI-bar' results in broad scale health improvements

Related Stories

Clinical studies show 'CHORI-bar' results in broad scale health improvements

April 22, 2015
A fruit-based micronutrient and fiber-dense supplement bar (the "CHORI-bar") conceived by Drs. Bruce Ames and Mark K. Shigenaga at Children's Hospital Oakland Research Institute (CHORI), was shown in clinical trials to improve ...

Want to improve your health? Focus on nutrition and not weight

August 5, 2015
If you are watching what you eat, working out, and still not seeing improvements in your cholesterol, blood pressure, blood sugar, etc., here's some hope. A new report appearing in the August 2015 issue of The FASEB Journal ...

Obesity worsens lung function for kids, young people with asthma

October 14, 2015
In adults with asthma, patients who are obese have worse lung function and more difficulty controlling their symptoms than asthma patients who are not obese. Following patients from childhood into young adulthood, a new study ...

Healthy diet reduces asthma symptoms

July 11, 2018
People who eat a healthy diet experience fewer asthma symptoms and better control of their condition, according to a new study published in the European Respiratory Journal.

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

January 3, 2017
A new study by researchers from the UCSF Benioff Children's Hospital Research Institute (CHORI) shows that a modest 4 milligrams of extra zinc a day in the diet can have a profound, positive impact on cellular health that ...

Study finds higher fat variation of DASH diet lowers blood pressure, triglycerides

January 11, 2016
The Dietary Approaches to Stop Hypertension (DASH) dietary pattern, which is high in fruits, vegetables and low fat dairy foods, significantly lowers blood pressure as well as low-density lipoprotein cholesterol (LDL-C) and ...

Recommended for you

Targeting sepsis, the leading cause of ICU deaths, with a nanocarrier-delivered microRNA

December 3, 2018
One in three patients who die in the U.S. dies of sepsis, according to the Centers for Disease Control and Prevention. It is one of the leading causes of death in intensive care units and, with an estimated price tag of $20 ...

Cells using sugar for metabolic process may fight inflammation

November 27, 2018
New research by a team from the FAMU-FSU College of Engineering has discovered that a type of adult stem cell found in a variety of tissues can be manipulated to enhance tissue regeneration and potentially treat inflammatory ...

To resolve inflammation, location matters

November 19, 2018
Health conditions that involve inflammation run the gamut, from multiple sclerosis and lupus to arthritis, diabetes, and cancer. While inflammation can serve as a normal response to help the body deal with injury or infection, ...

Patchy distribution of joint inflammation resolved

November 16, 2018
Chronic inflammatory rheumatic diseases such as rheumatoid arthritis (RA) and spondylo-arthritis (SpA) are chronic, disabling diseases with a poor outcome for loco-motoric function if left untreated. RA and SpA each affect ...

Discovery suggests new route to fight infection, disease

November 14, 2018
New research reveals how a single protein interferes with the immune system when exposed to the bacterium that causes Legionnaires' disease, findings that could have broad implications for development of medicines to fight ...

Can't exercise? A hot bath may help improve inflammation, metabolism, study suggests

November 14, 2018
Hot water treatment may help improve inflammation and blood sugar (glucose) levels in people who are unable to exercise, according to a new study. The findings are published ahead of print in the Journal of Applied Physiology.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.