Mammography screening also confers benefits on participants with interval cancer

August 31, 2018, Deutsches Aerzteblatt International
breast cancer
Mammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public Domain

Participants in the German mammography screening program (MSP) who have invasive breast cancer—including interval cancers—can, on the whole, undergo more sparing surgical treatment compared with non-participants. This is demonstrated by a study in the current issue of the Deutsches Ärzteblatt International. The tumor characteristics and prognostic markers of breast cancers detected in MSP participants at screening, in the interval following negative screening, as well as in non-participants were compared.

Data on 1531 newly diagnosed cases of invasive and in situ breast (DCIS, ductal carcinoma in situ) were evaluated in two certified breast care centers in Münster, Germany. Comprehensive information on , tumor biology, and primary surgical treatment was available for all cases.

In their retrospective observational study, Bettina Braun and co-authors conclude that was still at an early stage (DCIS) more frequently in screening participants compared with non-participants (23 percent versus 31 percent). Invasive cancers were smaller in participants (74 percent versus 55 percent in the T1 stage), could be operated on more frequently in a breast-conserving manner (75 percent versus 62 percent), and a guideline-based indication for adjuvant chemotherapy was less common in these patients (46 percent versus 52 percent). The authors emphasize that one can assume comparable figures in other screening regions.

Explore further: Lumpectomy + radiation may cut breast cancer mortality in DCIS

More information: Bettina Braun et al. Differences in breast cancer characteristics by mammography screening participation or non-participation, Deutsches Aerzteblatt Online (2018). DOI: 10.3238/arztebl.2018.0520

Related Stories

Lumpectomy + radiation may cut breast cancer mortality in DCIS

August 20, 2018
(HealthDay)—Treatment with lumpectomy and radiotherapy is associated with a reduction in breast cancer mortality versus lumpectomy or mastectomy alone among patients with ductal carcinoma in situ (DCIS), according to a ...

Combined digital screening best for detecting breast cancers

August 7, 2018
(HealthDay)—The combination of digital mammography (DM) and digital breast tomosynthesis (DBT) detects 90 percent more breast cancers than digital mammography alone, according to a study published in the August issue of ...

Breast screening program effective in preventing some invasive cancers

December 4, 2015
Screening for and treatment of an early form of breast cancer has been found to prevent subsequent invasive cancer, according to research led by Queen Mary University of London (QMUL).

Breast cancers detected at smaller size in women with implants

March 29, 2018
Breast augmentation with implants does not interfere with the ability to detect later breast cancers—in fact, cancers may be detected at a smaller size in breasts with implants, according to a study in the April issue of ...

Higher biopsy rates for women undergoing screening breast MRI

February 14, 2018
(HealthDay)—Women undergoing screening breast magnetic resonance imaging (MRI) have higher biopsy rates and significantly lower cancer yield findings compared with screening mammography alone, regardless of personal history ...

Individualized breast cancer screening catches more cancer

August 12, 2013
(HealthDay)—A breast cancer screening program tailored to participants' individual risk profiles has a higher-than-expected breast cancer detection rate in 40- to 49-year old women, according to a pilot study published ...

Recommended for you

Researchers identify a mechanism that fuels cancer cells' growth

November 14, 2018
Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified sodium glucose transporter 2, or SGLT2, as a mechanism that lung cancer cells can utilize to obtain glucose, which is key to their survival and promotes ...

A new approach to detecting cancer earlier from blood tests: study

November 14, 2018
Cancer scientists led by principal investigator Dr. Daniel De Carvalho at Princess Margaret Cancer Centre have combined "liquid biopsy", epigenetic alterations and machine learning to develop a blood test to detect and classify ...

New antibody breakthrough to lead the fight against cancer

November 14, 2018
Scientists at the University of Southampton have developed a new antibody that could hold the key to unlocking cancer's defence against the body's immune system.

Photoacoustic imaging may help doctors detect ovarian tumors earlier

November 14, 2018
Ovarian cancer claims the lives of more than 14,000 in the U.S. each year, ranking fifth among cancer deaths in women. A multidisciplinary team at Washington University in St. Louis has found an innovative way to use sound ...

Solving the mystery of NPM1 in acute myeloid leukemia

November 13, 2018
Although it has long been recognized that mutations of gene NPM1 play an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function.

Cognitive decline—radiation—brain tumor prevented by temporarily shutting down immune response

November 13, 2018
Treating brain tumors comes at a steep cost, especially for children. More than half of patients who endure radiation therapy for these tumors experience irreversible cognitive decline, a side-effect that has particularly ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.