The connection between alcoholism and depression

alcohol
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Alcoholism and depression often go hand-in-hand.

According to studies, alcoholism has risen sharply in the 2000s, to the point that one such study suggests that one in eight people meet the criteria as an alcoholic.

And affects many of the 140 million people worldwide struggling with alcohol use disorders. Only a few drugs are approved for treating the disorder. The goal of those medications is to reduce alcohol cravings, but they do not treat psychiatric disorders.

Help may be on the way.

Purdue University researchers have developed a technology that may treat by reducing while also having the potential to treat depression.

The Purdue team focused on a G , called the , which is a novel drug target that is different from the receptor in the body that binds . They developed drugs that bind to this new target and selectively activate a particular protein-signaling cascade of this receptor.

"We can then use this unique property of the drug to provide a therapeutic effect and avoid a side effect," said Richard van Rijn, an assistant professor of medicinal chemistry and molecular pharmacology, who led the research team. "Current types of delta opioids have been failing in clinical trials because, unlike ours, they activate multiple cascades, including those associated with increased side effects like seizures."

Credit: Purdue University

The Purdue drug has proven effective in preclinical tests in reducing alcohol use and has pharmacological properties that should enable it to reduce depression without inducing seizures.

"Our lab's research is focused on providing new hope for patients dealing with neurological disorders and addictions," van Rijn said.


Explore further

New target for treating alcoholism

More information: Bridget F. Grant et al. Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013, JAMA Psychiatry (2017). DOI: 10.1001/jamapsychiatry.2017.2161
Journal information: JAMA Psychiatry

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Sep 21, 2018
Alcohol is a depressant. How is that for a connection?

Sep 21, 2018
@chemhaznet1 Depression does not equate to depressant. A depressant is a category of drugs which includes sedatives and anaesthetics. A depressant means it inhibits the central nervous system, and does not relate to the MOOD DEPRESSION that you have suggested. The drug ICE is the opposite, it is a CNS stimulant, yet it too can lead people to depression.

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