Alzheimer's patients are more often hospitalized after initiating antibiotic use

antibiotic
Credit: CC0 Public Domain

People with Alzheimer's disease (AD) are more often hospitalized after antibiotic initiation than people without AD, a new study from the University of Eastern Finland shows. The risk of hospitalization was 40 per cent higher for persons with Alzheimer's disease. The findings were published in Journal of Alzheimer's Disease.

Out of individual antibiotics, persons with Alzheimer's disease were more often hospitalized than people without AD after the initiation of cephalexine, pivmecillinam, amoxicillin and doxycycline. Hospitalization was associated with pre-existing illnesses, such as epilepsy or cancer, and certain medications, such as antipsychotic and benzodiazepine use.

This study used data from a Finnish register-based cohort, which includes all persons diagnosed with Alzheimer's disease in Finland during 2005–2011. The researchers analysed 34,785 persons who used in an outpatient setting after their Alzheimer's disease diagnosis, and their comparison persons matched according to age, sex and region of residence.

Previous studies have shown that infections are a significant cause of hospitalization in persons with dementia. This study is the first to document hospitalization after antibiotic initiation. These results confirm the role of infections as a cause of hospitalization in persons with Alzheimer's disease.


Explore further

Antidepressant use begins years before Alzheimer's diagnosis

More information: Heli Järvinen et al. Hospitalization after Oral Antibiotic Initiation in Finnish Community Dwellers with and without Alzheimer's Disease: Retrospective Register-Based Cohort Study, Journal of Alzheimer's Disease (2018). DOI: 10.3233/JAD-180125
Provided by University of Eastern Finland
Citation: Alzheimer's patients are more often hospitalized after initiating antibiotic use (2018, September 18) retrieved 17 February 2019 from https://medicalxpress.com/news/2018-09-alzheimer-patients-hospitalized-antibiotic.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
21 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more