Multiple pathways explain age-linked increase in dementia risk

September 25, 2018

(HealthDay)—Multiple pathways account for the age-related increases in dementia risk, according to a study recently published in the Annals of Neurology.

Melinda C. Power, Sc.D., from the George Washington University Milken Institute School of Public Health in Washington, D.C., and colleagues used data from 1,362 autopsied participants of three community-based clinicopathological cohorts. A series of structural equation models summarizing a priori hypothesized neuropathological pathways between age and dementia risk were estimated individually and collectively.

Forty-four percent of the sample had a clinical dementia diagnosis at the time of death. The researchers found that vascular, amyloid/tau, neocortical Lewy body, and TAR DNA-binding protein 43 (TDP-43)/hippocampal sclerosis pathology pathways each accounted for a considerable proportion of the correlation between age and dementia when considered individually. The four pathways fully accounted for all variance in dementia risk previously attributed to age when considered collectively. Amyloid/tau, neocortical Lewy bodies, and TDP-43/hippocampal sclerosis pathways were interdependent; this was due to the importance of amyloid beta plaques in all three pathways. There was variation in the importance of the pathways, with the vascular and the three inter-related pathways accounting for 32 and 68 percent, respectively, of the association between age and dementia.

"Age-related increases in risk can be attributed to accumulation of multiple pathologies, each of which contributes to ," the authors write. "Multipronged approaches may be necessary if we are to develop effective therapies."

Explore further: Age, sex, APOE genotype identify alzheimer's, dementia risk

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Age, sex, APOE genotype identify alzheimer's, dementia risk

September 21, 2018
(HealthDay)—Age, sex and apolipoprotein E (APOE) genotype can identify groups at high 10-year risk for Alzheimer's disease and all dementia, according to a study published Sept. 4 in CMAJ, the journal of the Canadian Medical ...

Stroke doubles dementia risk, concludes large-scale study

August 31, 2018
People who have had a stroke are around twice as likely to develop dementia, according to the largest study of its kind ever conducted.

Smoking linked to higher dementia risk

September 6, 2018
In an Annals of Clinical and Translational Neurology analysis of nationwide health claims from Korea, men who smoked had an elevated risk of dementia.

Tiny blood vessels in the brain could be the key in treating vascular dementia

June 22, 2017
Researchers from the University of Southampton are to study tiny channels embedded in the walls of blood vessels in the brain to assess their impact on dementia.

Abnormal brain protein may contribute to Alzheimer's disease development

September 30, 2016
A recently-recognized pathologic protein in the brain may play a larger role in the development of clinical Alzheimer's disease dementia than previously recognized, according to a study by researchers at Rush University Medical ...

Recommended for you

Does diabetes damage brain health?

December 14, 2018
(HealthDay)—Diabetes has been tied to a number of complications such as kidney disease, but new research has found that older people with type 2 diabetes can also have more difficulties with thinking and memory.

Amyloid pathology transmission in lab mice and historic medical treatments

December 13, 2018
A UCL-led study has confirmed that some vials of a hormone used in discontinued medical treatments contained seeds of a protein implicated in Alzheimer's disease, and are able to seed amyloid pathology in mice.

Study links slowed brainwaves to early signs of dementia

December 13, 2018
To turn back the clock on Alzheimer's disease, many researchers are seeking ways to effectively diagnose the neurodegenerative disorder earlier.

New discoveries predict ability to forecast dementia from single molecule

December 11, 2018
Scientists who recently identified the molecular start of Alzheimer's disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time—a form of personalized ...

Researchers classify Alzheimer's patients in six subgroups

December 5, 2018
Researchers studying Alzheimer's disease have created an approach to classify patients with Alzheimer's disease, a finding that may open the door for personalized treatments.

Neuroscientists pinpoint genes tied to dementia

December 3, 2018
A UCLA-led research team has identified genetic processes involved in the neurodegeneration that occurs in dementia—an important step on the path toward developing therapies that could slow or halt the course of the disease. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.