Beta-blockers in 1st trimester do not up congenital malformations
Brian T. Bateman, M.D., from Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues estimated the risks for major congenital malformations associated with first-trimester exposure to β-blockers using data from health registries in the five Nordic countries and the U.S. Medicaid database.
The researchers found that the β-blocker-associated pooled adjusted relative risk (RR) and risk difference per 1,000 persons exposed (RD1000) were 1.07 (95 percent confidence interval, 0.89 to 1.3) and 3 (confidence interval, −6.6 to 12.6) for any major malformation; 1.12 (95 percent confidence interval, 0.83 to 1.51) and 2.1 (confidence interval, −4.3 to 8.4) for any cardiac malformation; and 1.97 (95 percent confidence interval, 0.74 to 5.25) and 1 (confidence interval, −0.9 to 3) for cleft lip or palate. Based on the U.S. cohort data only, the adjusted RR and RD1000 were 1.37 (95 percent confidence interval, 0.58 to 3.25) and 1 (confidence interval, −2 to 4) for central nervous system malformations.
"The potential risks to the fetus must be balanced against the risks to the mother associated with untreated hypertension," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
Editorial (subscription or payment may be required)
Copyright © 2018 HealthDay. All rights reserved.