A diagnostic tool to save lives and prevent brain damage

A diagnostic tool to save lives and prevent brain damage
By examining the patient's eye with ultrasound, doctors can reveal high brain pressure. In the past, the doctors had to go through the patient's skull to measure this. The method was developed by SINTEF in cooperation with the Red Cross War Memorial Children's Hospital in South Africa. Credit: NiSonic

A new study confirms the efficacy of a new diagnostic tool that utilises ultrasound to measure intracranial pressure following accidents. The technology will now be provided with artificial intelligence so that ambulance personnel can carry out examinations at accident scenes.

Elevations in intracranial pressure following an accident can lead to brain injury and damage to the spinal cord. Currently, such increases are detected directly using a sensor that is surgically inserted into the patient's head via a hole made in the skull. The procedure must be carried out in an operating theatre. Both this and the sensor are expensive and resource-demanding.

Results from a new study confirm that the diagnostics tool developed by a team of researchers at SINTEF, in collaboration with the South African paediatric neurosurgeon Llewellyn Padayachy, can address this problem. The tool is an that can detect elevations in intracranial pressure by making examinations of the eye.

It all began in Cape Town

Padayachy had the idea for this revolutionary invention while he was working with Norwegian ultrasound researchers at the Red Cross War Memorial Children's Hospital in Cape Town, one of South Africa's largest paediatric hospitals.

The project was launched by a study completed in 2016 involving 16 patients in South Africa. Half were suffering from elevations in cranial pressure, while the remaining eight exhibited normal levels.

"We obtained good results with high levels of clinical accuracy, and using these were able to further develop the ", says SINTEF researcher Reidar Brekken.

The research group in Cape Town has recently completed a new study of 28 patients, in which the ultrasound data were analysed using software developed by the team at SINTEF.

"We knew what answers we would get from the first study, while for the second we carried out a blind analysis", says Brekken. "Since the results we obtained were just as good, I'm certain that we should be pursuing this further", he says.

A follow-up study has recently been published in the journal Operative Neurosurgery.

Artificial intelligence

The first version of the ultrasound device was manually-operated, and this demanded high levels of specialist expertise on the part of the operator. Now, however, the research team has advanced the technology a step further by providing it with artificial intelligence. This means that many more people can operate the tool because it is more user-friendly. This in turn makes it possible for intracranial pressure measurements to be carried out at an earlier stage.

"For the most part, artificial intelligence assists by automating the measurement process", says Brekken. "Whereas previously we had to input data manually and identify structures displayed on the resulting image, our aim now is that the only thing an operator has to do is place the ultrasound probe on the patient's eye. The machine will then identify the structures and deliver the measurement results", he says.

It is only in recent years that it has been possible to fully automate examination of the images.

"Developments in artificial intelligence are advancing fast, and the new device can interpret images better than human operators", says SINTEF researcher Erik Smistad. "The major benefit of this technology is that it is far less dependent on the operator and provides more objective measurements", he says.

Our aim now is to manufacture a tool that can be used early in the patient pathway, ideally by ambulance personnel.

A diagnostic tool to save lives and prevent brain damage
South African doctor Llewellyn Padayachy tests the ultrasound device with the probe against the eyelid to the patient. Credit: SINTEF

"If clinical assessments can be made at accident scenes, this will make a big difference later in the patient pathway", says Brekken. "It will help to save lives and prevent potential brain damage. It will also be less expensive to implement because there will be no need to transport patients for costly surgical interventions in operating theatres in order to perform an examination", he says.

Tests on Norwegian patients

In the future, technological and clinical research will be key to the advancement and quality assurance of the technology.

"We will also have to develop the component into a diagnostics tool", says Brekken. "Even now, the machine handles a relatively large volume of data, but we will need more capacity if we are to train it to make the right choices", he says.

There are plans in the immediate future to further test the technology on 200 patients suffering from head injuries. The studies will be carried out in collaboration with professor and neurosurgeon Eirik Helseth at the UllevÄl University Hospital in Oslo.

"This will be the first time that the technology will be tested on adults, and entirely on with head injuries", says Brekken. "It will be a particularly important study, and a landmark in the development of this diagnostic tool", he says.

Researchers are also looking into different ways of benefiting from this technology above and beyond the examination of .

"It isn't just traumas such as blows to the head that cause elevations in ", says Brekken. "Other neurological conditions, such as brain tumours and haemorrhaging can also result in pressure increases", he says.


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