Hormone therapy not beneficial in subclinical hypothyroidism

Hormone therapy not beneficial in subclinical hypothyroidism
(HealthDay)—Thyroid hormone therapy is not associated with improvements in general quality of life or thyroid-related symptoms in non-pregnant adults with subclinical hypothyroidism, according to a review published in the Oct. 2 issue of the Journal of the American Medical Association.

Martin Feller, M.D., from the University of Bern in Switzerland, and colleagues conducted a systematic literature review to identify randomized clinical trials that compared thyroid therapy to placebo or no therapy in non-pregnant adults with subclinical hypothyroidism. Their analysis included 21 studies with 2,192 adults.

The researchers found that after treatment (range, three to 18 months), thyroid hormone therapy was associated with a reduction in the mean thyrotropin value to the normal reference range versus placebo, but it was not associated with benefit regarding general quality of life or thyroid-related symptoms. Included studies had a low risk of bias and moderate- to high-quality evidence.

"These findings do not support the routine use of thyroid hormone in with subclinical hypothyroidism," the authors write.

One author disclosed financial ties to the pharmaceutical industry.


Explore further

Subclinical hyperthyroidism associated with an increased risk of hip and other fractures

More information: Abstract/Full Text (subscription or payment may be required)

Copyright © 2018 HealthDay. All rights reserved.

Citation: Hormone therapy not beneficial in subclinical hypothyroidism (2018, October 15) retrieved 18 January 2019 from https://medicalxpress.com/news/2018-10-hormone-therapy-beneficial-subclinical-hypothyroidism.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more