New method estimates risk for recurrence in breast cancer

October 30, 2018

(HealthDay)—The risk for breast cancer recurrence can be extracted using disease-specific survival data, according to a study published online Oct. 18 in Cancer Epidemiology, Biomarkers & Prevention.

Angela B. Mariotto, Ph.D., from the National Cancer Institute in Bethesda, Maryland, and colleagues presented a novel method for estimating the risk for recurrence. The method was based on an illness-death process coupled with a mixture cure model. The risk for recurrence was inferred from the estimated among the noncured fraction as well as published data on survival after recurrence. The method was applied to disease-specific survival curves from female breast cancer cases without a prior cancer diagnosis.

The researchers found a higher risk for recurrence among women who were diagnosed with breast cancer at an older age or in an earlier period (1992-1999 versus 2000-2013), had a more advanced stage of disease, or had hormone receptor (HR)-negative tumors. The projected percent recurring within five years was 2.5, 9.6, and 34.5 percent for stages I, II, and III HR-positive tumors and 6.5, 20.2, and 48.5 percent for stages I, II, and III HR-negative tumors among women diagnosed at ages 60 to 74 years in 2000 to 2013. Soon after diagnosis, HR-positive cases had a lower risk for , but their risk persisted longer than that of HR-negative cases. The results showed a high degree of robustness to model assumptions.

"We anticipate that the approach will be applicable to other cancers, in particular those amenable to mixture cure modeling, enhancing our understanding of the burden of in the population," the authors write.

Explore further: Pregnancy poses no greater risk to breast cancer survivors

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Pregnancy poses no greater risk to breast cancer survivors

October 26, 2017
A recent study published in the Journal of the National Cancer Institute indicates that pregnancy does not incur a greater risk of relapse for survivors of breast cancer. The safety of pregnancy for women with history of ...

Study estimates number of US women living with metastatic breast cancer

May 18, 2017
A new study shows that the number of women in the United States living with distant metastatic breast cancer (MBC), the most severe form of the disease, is growing. This is likely due to the aging of the U.S. population and ...

TNFi not linked to increased cancer recurrence in RA patients

August 24, 2018
(HealthDay)—For patients with rheumatoid arthritis (RA), treatment with tumor necrosis factor inhibitors (TNFi) is not associated with increased risk for cancer recurrence, according to a study published online Aug. 14 ...

Biological factors don't fully explain racial disparities for breast cancer type

December 7, 2017
Higher risk of recurrence for black women with hormone receptor-positive, HER2-negative breast cancer compared with white women cannot be completely explained by underlying biological factors, University of North Carolina ...

Pregnancy not dangerous for women who had breast cancer

June 4, 2017
Becoming pregnant after a diagnosis of breast cancer does not raise the risk of the cancer returning, said the largest study of its kind to date, released Saturday at a major cancer conference.

Women with DCIS at lowest risk of recurrence if they are post-menopausal or ER+

March 21, 2018
Patients with an early form of breast cancer are less likely to suffer a recurrence if they are post-menopausal or if their tumour is oestrogen receptor positive, according to research presented at the 11th European Breast ...

Recommended for you

Researchers stop spread of cancer in mice by blocking specific molecules

November 21, 2018
Melanoma skin cancer tumors grow larger and are more likely to metastasize due to interactions between a pair of molecules, according to experiments in mice and human cells. The results may restore the potential for a type ...

A study suggests that epigenetic treatments could trigger the development of aggressive tumours

November 20, 2018
A study headed by the Institute for Research in Biomedicine (IRB Barcelona) and published in the journal Nature Cell Biology examined whether the opening of chromatin (a complex formed by DNA bound to proteins) is the factor ...

'Druggable' cancer target found in pathway regulating organ size

November 20, 2018
It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. It's further known that a major player in this pathway, ...

Redefining colorectal cancer subtypes

November 20, 2018
There is a long-standing belief that colorectal cancer (CRC), which causes some 50,000 deaths in the United States each year, can be categorized into distinct molecular subtypes. In a paper published recently in the journal Genome ...

Proposed cancer treatment may boost lung cancer stem cells, study warns

November 20, 2018
Epigenetic therapies—targeting enzymes that alter what genes are turned on or off in a cell—are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant. Researchers at Boston ...

New drug discovery could halt spread of brain cancer

November 19, 2018
The tissues in our bodies largely are made of fluid. It moves around cells and is essential to normal body function.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.