Advancement in drug therapies may provide new treatment for Cutaneous leishmaniasis

Advancement in drug therapies may provide new treatment for Cutaneous leishmaniasis
"Confocal microscopy on L. tropica infected macrophages treated with 0.1 μM of Imiquimod or EAPB0503 for 10h." Credit: Hajj, et al. (2018)

Cutaneous leishmaniasis (CL) is a parasitic infection caused by Leishmania parasite. CL cases have increased dramatically in Syria and neighboring countries due to conflict-related displacement of Syrians. A study published in PLOS Neglected Tropical Diseases by Rana El Hajj at the American University of Beirut, Lebanon describes the development of a novel immunomodulatory analog that may be an effective treatment of CL.

Currently used therapies against CL may lead to partial or complete cure. However, they associate with many limitations, including repetitive painful injections, lack of availability, expensive cost, and emergence of resistant strains. Furthermore, their efficacy remains hindered by the patient's age and immune system. Researchers investigated the pre-clinical efficacy of an immunomodulatory drug, Imiquimod and one of its analogs, EAPB0503 on two strains (Leishmania major and Leishmania tropica) causing CL in the Middle East Area. They also tested these drugs on freshly isolated parasites from patients' biopsies and proved their leishmanicidal potency.

According to the authors, "Our findings establish Imiquimod as a strong candidate for treating L. tropica and show the higher potency of its EAPB0503 against CL". Their research is a promising advancement for the development of effective therapies for CL.


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More information: El Hajj R, Bou Youness H, Lachaud L, Bastien P, Masquefa C, et al. (2018) EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica. PLOS Neglected Tropical Diseases 12(11): e0006854. doi.org/10.1371/journal.pntd.0006854
Journal information: PLoS Neglected Tropical Diseases

Citation: Advancement in drug therapies may provide new treatment for Cutaneous leishmaniasis (2018, November 21) retrieved 27 October 2020 from https://medicalxpress.com/news/2018-11-advancement-drug-therapies-treatment-cutaneous.html
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