Arterial stiffness may predict dementia risk

November 21, 2018

(HealthDay)—Arterial stiffness may predict dementia risk, independent of subclinical brain damage, according to a study recently published in the Journal of Alzheimer's Disease.

Chendi Cui, from the University of Pittsburgh Graduate School of Public Health, and colleagues used data from 532 nondemented older adults participating in the Cardiovascular Health Study Cognition Study. Participants had annual cognitive exams from 1998-1999 through 2013. Carotid-femoral pulse wave velocity (cfPWV) was measured for 356 participants (mean age, 78 years; 59 percent women) between 1996 and 2000.

The researchers found that during 15 years, 212 (59.6 percent) participants developed dementia, with a median time from cfPWV measurement of four years. cfPWV was significantly associated with an increased risk for dementia after adjustment for age and sex, but systolic blood pressure, mean arterial pressure, and pulse pressure were not. After further adjustment for education, race, APOE ε4, diabetes, body mass index, mean arterial pressure, and antihypertensive medication, cfPWV remained significantly associated with (hazard ratio, 1.6). Results remained after additional adjustment for baseline global cognition, subclinical brain measures, and coronary artery calcification. Higher cfPWV was also associated with lower physical activity intensity and higher , heart rate, and waist circumference measured five years prior.

"It's very surprising that adjusting for subclinical brain disease markers didn't reduce the association between and at all," Cui said in a statement.

Explore further: Long-running study identifies modifiable dementia risk factor in older adults

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Long-running study identifies modifiable dementia risk factor in older adults

October 16, 2018
For older adults, it may seem as though the die is already cast regarding their odds of developing dementia, but new research from the University of Pittsburgh has identified a dementia risk factor among older adults that ...

Parathyroid hormone linked to arterial stiffness in T1DM

January 11, 2017
(HealthDay)—In individuals with type 1 diabetes, parathyroid hormone (PTH) is associated with arterial stiffness, even after adjustment for multiple confounding variables, according to research published online Jan. 6 in ...

HbA1c tied to progression of aortic stiffness without diabetes

February 7, 2017
(HealthDay)—For individuals without diabetes, glycated hemoglobin (HbA1c) is associated with accelerated progression of aortic stiffness, according to a study published online Jan. 25 in Diabetes Care.

Vascular brain injury is evident in people in their 40s

March 28, 2016
A large, multi-center study led by the UC Davis School of Medicine for the first time has shown that people as young as their 40s have stiffening of the arteries that is associated with subtle structural damage to the brain ...

Arterial stiffness linked to incidence of diabetes

October 29, 2017
(HealthDay)—Increased arterial stiffness, as measured by carotid-femoral pulse wave velocity (c-f PWV), is associated with increased incidence of diabetes, according to a study published online Sept. 29 in Diabetes Care.

Stiffening of blood vessels may point to dementia risk

September 21, 2018
Arterial stiffness among people with mild cognitive impairments could put them at higher risk for progressing to dementia, which may include Alzheimer's disease, according to a new study exploring the connection between the ...

Recommended for you

Researchers classify Alzheimer's patients in six subgroups

December 5, 2018
Researchers studying Alzheimer's disease have created an approach to classify patients with Alzheimer's disease, a finding that may open the door for personalized treatments.

Neuroscientists pinpoint genes tied to dementia

December 3, 2018
A UCLA-led research team has identified genetic processes involved in the neurodegeneration that occurs in dementia—an important step on the path toward developing therapies that could slow or halt the course of the disease. ...

Detecting signs of neurodegeneration earlier and more accurately

November 30, 2018
Signs of neurodegenerative diseases, appearing years before the emergence of clinical manifestations, can be detected during the examination of medical samples by means of fluorescence microscopy by using new sensitive and ...

Never-before-seen DNA recombination in the brain linked to Alzheimer's disease

November 21, 2018
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer's disease brains. The study, published today ...

New information on the pathological mechanisms of Alzheimer's disease

November 21, 2018
Researchers at the University of Helsinki have discovered a mechanism by which harmful tau protein aggregates are transmitted between neurons. Alongside amyloid plaques, tau aggregates in the brain are a significant factor ...

DNA vaccine reduces both toxic proteins linked to Alzheimer's

November 20, 2018
A DNA vaccine tested in mice reduces accumulation of both types of toxic proteins associated with Alzheimer's disease, according to research that scientists say may pave the way to a clinical trial.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.