Certain SGLT2 inhibitors, GLP-1 RAs for T2DM also cut CV risk

November 30, 2018

(HealthDay)—Certain sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) demonstrate significant cardiovascular (CV) benefit and should be used for reducing CV risk in patients with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD), according to a report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways published online Nov. 26 in the Journal of the American College of Cardiology.

Sandeep R. Das, M.D., M.P.H., from UT Southwestern Medical Center in Texas, and colleagues provide guidance on use of glucose-lowering agents for reducing CV risk in patients with T2D and clinical ASCVD.

The authors note that specific medications in these classes can reduce rates of acute myocardial infarction, stroke, and CV death; SGLT2 inhibitors can also reduce heart failure hospitalizations. These benefits are independent of their impact on hemoglobin A1c. Clinician-patient discussions regarding use of these agents should include discussion of which agent is most appropriate; patient preferences and medical history can guide this decision. An SGLT2 inhibitor and GLP-1 RA with proven CV benefit should be added to the treatment regimen of patients with T2D and clinical ASCVD treated with metformin. No definitive data show evidence of in reducing CV risk in patients not treated with metformin.

"We anticipate that the algorithms proposed here will change as new evidence emerges, but that the overarching goal of improving CV outcomes in patients with T2D and clinical ASCVD will remain consistent," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: AHA: guidelines stress healthy lifestyle for lowering cholesterol

More information: Abstract/Full Text

Related Stories

AHA: guidelines stress healthy lifestyle for lowering cholesterol

November 15, 2018
(HealthDay)—A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course, according to a guideline published online Nov. 14 in Circulation to coincide with the ...

Higher risk for amputation, DKA with SGLT2 inhibitors for T2DM

November 19, 2018
(HealthDay)—Use of sodium glucose cotransporter 2 (SGLT2) inhibitors is associated with an increased risk for lower-limb amputation and diabetic ketoacidosis compared with use of glucagon-like peptide 1 (GLP1) receptor ...

New EASD-ADA consensus guidelines on managing hyperglycaemia in type 2 diabetes launched at EASD meeting

October 5, 2018
Following a review of the latest evidence —including a range of recent trials of drug and lifestyle interventions—the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) have ...

Certain diabetes drugs linked to increased risk of lower limb amputation

November 14, 2018
Use of sodium glucose cotransporter 2 (SGLT2) inhibitors to treat type 2 diabetes is associated with an increased risk of lower limb amputation and diabetic ketoacidosis (a serious diabetes complication) compared with another ...

Study: Improvement in glycemic parameters by adding dapagliflozin to metformin in T2D

October 1, 2018
Researchers used continuous glucose monitoring (CGM) to assess the effects of adding dapagliflozin to a regimen of either metformin or insulin in patients with type 2 diabetes (T2D) and found significant reductions in mean ...

Coronary artery calcium may be best indicator of CVD risk

September 4, 2017
(HealthDay)—The cardiovascular event rate is low for patients with no coronary artery calcium (CAC), which improves overall prediction among patients thought to be at risk of atherosclerotic cardiovascular disease (ASCVD), ...

Recommended for you

Researchers study abnormal blood glucose levels of discharged patients

December 14, 2018
University of Minnesota Medical School researchers decided to delve into an area where little data currently exists. They wanted to know what happens after these patients with abnormal blood glucose measurements are discharged? ...

Can stem cells help a diseased heart heal itself? Researchers achieve important milestone

December 14, 2018
A team of Rutgers scientists, including Leonard Lee and Shaohua Li, have taken an important step toward the goal of making diseased hearts heal themselves—a new model that would reduce the need for bypass surgery, heart ...

Researchers zero in on potential therapeutic target for diabetes, associated diseases

December 14, 2018
A recent study led by researchers in Texas A&M University's department of nutrition and food science shows how a novel regulatory mechanism serves as an important biomarker for the development of diabetes, as well as a potential ...

Does diabetes damage brain health?

December 14, 2018
(HealthDay)—Diabetes has been tied to a number of complications such as kidney disease, but new research has found that older people with type 2 diabetes can also have more difficulties with thinking and memory.

Higher risk of heart attack on Christmas Eve

December 12, 2018
The risk of heart attack peaks at around 10pm on Christmas Eve, particularly for older and sicker people, most likely due to heightened emotional stress, finds a Swedish study in this week's Christmas issue of The BMJ.

Your weight history may predict your heart failure risk

December 12, 2018
In a medical records analysis of information gathered on more than 6,000 people, Johns Hopkins Medicine researchers conclude that simply asking older adult patients about their weight history at ages 20 and 40 could provide ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.