Brain activity predicts fear of pain

Brain activity predicts fear of pain
The model performance (r, MSE) characterizes the strength of relationship between true and predicted labels. Condition and region weights show the predictive contribution of the two different conditions (harmful, harmless) and fear-related brain regions (parcellated according689 to the AAL atlas, L = left, R = right) to the final decision function of each MKL model (questionnaires A-E 690 with model performance p < 0.05, FDR- and uncorrected). Brain regions (feature set): Thalamus (1), Hippocampus (2), Amygdala (3), Insula (4), mOFC: Rectus (5),692 Frontal_Sup_Orb (6), Frontal_Med_Orb (7), lateral OFC: Frontal_Mid_Orb (8), Frontal_Inf_Orb (9), mPFC: Frontal_Sup_Medial (10), anterior cingulate cortex (Cingulum_Ant (11). indicates not visible contralateral homologue. Credit: Meier et al., eNeuro (2018)

Researchers applied a machine learning technique that could potentially translate patterns of activity in fear-processing brain regions into scores on questionnaires used to assess a patient's fear of pain. This neuroscientific approach, reported in eNeuro, may help reconcile self-reported emotions and their neural underpinnings.

Pain-related fear is typically assessed with various questionnaires, often used interchangeably, that ask patients how they feel about their clinical pain. However, it is unclear to what extent these self-reports measure fear and anxiety, which are known to involve different , and perhaps other psychological constructs.

Michael Meier and colleagues from Petra Schweinhardts' lab at the Balgrist University Hospital in Zurich, Switzerland, addressed this ambiguity by imaging the brains of patients with as they watched evoking harmful (bending) and harmless (walking) activities for the back. Participants' brain activity was predictive of their scores on the various questionnaires. Importantly, different questionnaires were associated with distinct patterns of neural activity.

These results suggest similar questionnaires may measure different emotional states.


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More information: Pain-related fear - Dissociable neural sources of different fear constructs, eNeuro, www.eneuro.org/lookup/doi/10.1 … /ENEURO.0107-18.2018
Citation: Brain activity predicts fear of pain (2018, December 24) retrieved 22 October 2019 from https://medicalxpress.com/news/2018-12-brain-pain.html
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