Investigational cream may help patients with inflammatory skin disease

A study published in the British Journal of Dermatology indicates that an investigational nonsteroidal topical cream (PAC-14028) may be effective for treating atopic dermatitis, one of the most common inflammatory skin diseases.

The trial involved a cream that blocks the transient receptor potential vanilloid subfamily, member 1, an involved in the perception of pain. This channel also contributes to inflammation and itchy skin in patients with .

In the 8-week, randomized, double-blind, multicentre, study that enrolled 194 adults with mild to moderate atopic dermatitis, the cream improved clinical symptoms and signs with a favourable safety profile.

According to the authors, a phase III clinical trial is underway to test if the topical medicine is safe and effective in teens and adults.

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More information: British Journal of Dermatology (2019). DOI: 10.1111/bjd.17455
Provided by Wiley
Citation: Investigational cream may help patients with inflammatory skin disease (2019, January 9) retrieved 21 March 2019 from
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