Ultrasound for thrombosis prevention

Ultrasound for thrombosis prevention
Petri dishes with fibrin clots extracted from the experimental system one hour after the start of the coagulation processes. Credit: Image courtesy of the researchers

A new approach for the prevention of thrombosis was proposed by researchers from the Moscow Institute of Physics and Technology (MIPT) and the Russian National Research Center for Hematology (NRCH).

In modern clinical practice, thrombolysis is performed when thrombi formed in pose a threat to a patient's life. Thrombolytic procedures themselves are associated with a high risk, as they can cause acute bleeding. Sometimes the necessity of appears urgently, for example in myocardial infarction and stroke. In these cases, onset-to-treatment time is a key limitation of thrombolytic therapy efficiency. Therefore, the implementation of a technique for early diagnostics and monitoring of thrombus formation is a matter of great interest.

"We have chosen as a method for monitoring, since it is noninvasive and allows measurements in deep-lying large vessels, in which thrombus formation is most dangerous," says Dmitry Ivlev, an MIPT graduate and a researcher at NRCH.

In the paper published in PLOS ONE, a new approach based on ultrasonic registration of blood coagulation in its early stages has been developed. Continuous ultrasonic monitoring of the blood's aggregate state was performed using the in vitro blood flow model. An injection of a fibrinolytic drug was performed automatically on the basis of ultrasonic data. The authors have shown that the ultrasonic technique allows detecting the stage of coagulation at which timely pharmacological intervention leads to a fast and complete dissolution of the fibrin clots being formed in blood flow.

According to the head of the research group, professor Georgy Guria of MIPT's living systems physics department, who also heads a laboratory at NRCH, "due to the progress in the field of compact ultrasonic sensors, our work opens new prospects for creation of wearable devices for timely medical assistance to patients with a high risk of thrombosis."


Explore further

In vivo skin imaging technology developed

More information: Dmitry A. Ivlev et al, Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulation, PLOS ONE (2019). DOI: 10.1371/journal.pone.0211646
Journal information: PLoS ONE

Citation: Ultrasound for thrombosis prevention (2019, March 7) retrieved 22 August 2019 from https://medicalxpress.com/news/2019-03-ultrasound-thrombosis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more