Common oral infections in childhood may increase the risk of atherosclerosis in adulthood

Atherosclerosis is a condition affecting the cardiovascular system. If atherosclerosis occurs in the coronary arteries (which supply the heart) the result may be angina pectoris, or in worse cases a heart attack. Credit: Wikipedia/CC BY 3.0

A Finnish 27-year follow-up study suggests that common oral infections in childhood, caries and periodontal diseases, are associated with an increased risk of atherosclerosis in adulthood.

The association between and adulthood carotid atherosclerosis was observed in The Cardiovascular Risk in Young Finns Study, an ongoing prospective cohort.

"The observation is novel, since there are no earlier follow-up studies on childhood oral infections and the risk of cardiovascular diseases," says docent Pirkko Pussinen from the University of Helsinki.

More progressed oral infections and inflammations—endodontic lesions and periodontitis—are known to be associated with several factors and disease risk in adults. In adults periodontitis in particular has been studied extensively, and currently it is considered an for atherosclerotic vascular diseases. The treatment of periodontitis is also known to decrease .

The association between childhood oral infections and atherosclerosis was found in a study conducted at the University of Helsinki, Department of Oral and Maxillofacial Diseases, in collaboration with the national Cardiovascular Risk in Young Finns Study research group. The study was published in JAMA Network Open.

The study was initiated in 1980, when clinical oral examinations were conducted for 755 children aged 6, 9, and 12 years. The follow-up ended in 2007, when the carotid artery intima-media thickness was measured in an ultrasound examination of participants, who were then 33, 36, and 39 years old.

The follow-up was 27 years, and cardiovascular were measured at several time points. A cumulative exposure to the risk factor was calculated in both childhood and adulthood. The signs of oral infections and inflammation collected in the study included caries, fillings, bleeding on probing, and probing pocket depth.

The more signs of oral infections, the higher risk for atherosclerosis

From all children, 68%, 87%, and 82% had bleeding, caries, and fillings, respectively. There were no differences between the boys and the girls. Slight periodontal pocketing was observed in 54% of the children, and it was more frequent in the boys than in the girls. Only 5% of the examined mouths were totally healthy, whereas 61% and 34% of the children had one to three signs and four signs of oral infections, respectively.

"The number of signs associated significantly with the cumulative exposure to the cardiovascular risk factors in adulthood, but especially in childhood," says professor Markus Juonala from the University of Turku.

Both and periodontal diseases in childhood were significantly associated with carotid artery intima-media thickness in adulthood. Thickening of the carotid artery wall indicates the progression of atherosclerosis and an increased risk for myocardial or cerebral infarction.

The researchers emphasise, in conclusion: "Oral infections were an independent risk factor for subclinical ; and their association with cardiovascular risk factors persevered through the entire follow-up. Prevention and treatment of oral infections is important already in childhood."

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More information: Pussinen PJ et al. Juonala M. Association of Childhood Oral Infections with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood. JAMA Netw Open. 2019;2(4): e192523. DOI: 10.1001/jamanetworkopen.2019.2523
Journal information: JAMA Network Open

Citation: Common oral infections in childhood may increase the risk of atherosclerosis in adulthood (2019, April 26) retrieved 23 October 2019 from
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Apr 26, 2019
Emphasis that this an "association" or correlation, not a causal relationship. As we know infections cause inflammation and inflammation can exasperate injuries to the endothelial cells which in turn results in arteriosclerosis. So it would seem that a predisposition to periodontal disease is a good indication of the strength of immune system overall, and consequently the predisposition to the inflammation that causes arteriosclerosis.

Also people who care for the health of their teeth and gums are generally more health conscience overall. Consequently less periodontal disease and fewer unhealthy habits that cause arteriosclerosis.

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