Study shows thousands of neurons becoming active during thirst and quench cycle

drinking water
Credit: CC0 Public Domain

A team of researchers with Stanford University and Howard Hughes Medical Institute has used a new tool to record activation of thousands of neurons due to thirst and quenching in a mouse brain. In their paper published in the journal Science, the group describes their study of the mouse brain during cycles of thirst and drinking water and what they found.

Being thirsty is serious business—the human body cannot go very long without an intake of water. And because it is such a critical activity, the researchers with this new effort suspected that many parts of the brain were likely involved in triggering the urge for water by creating the sensation of thirst and by reacting to the ingestion of a liquid. To find out if this was, indeed, the case, the researchers used a new tool to study mice going through thirst and quenching cycles.

The new device is called a Neuropixel probe, and it allows researchers to record the neurological activity of thousands of at once—all along a very thin shaft that can be inserted directly into the brain in a minimally invasive way. Using the new tool allowed the researchers to record 23,881 neurons firing over 87 sessions, covering 34 in 21 mice.

The goal the team set was to record neurons firing in different parts of the brain during the thirst and quench cycle as part of an effort to learn more about how the brain works during such a critical process. They were able to detect thirst in a by monitoring and blood osmolarity, which, they note, the brain also monitors using cells on the subfornical organ. When levels are low, the cells send a signal to other parts of the brain to instigate thirst sensations.

The mice used in the study had been trained to respond to odor cues indicating the presence of water, and taught that they could gain access to it by licking a spout. They were also placed in a device that kept their heads still during the brain study.

The researchers report that large parts of all regions were activated when experiencing thirst, and also when drinking in response to thirst. They were also able to recognize patterns in neuronal firing depending on which part of the and quench cycle was in progress and the degree of thirstiness of the mouse. They concluded by repeating prior experiments that showed it was possible to force a mouse to feel thirsty and to drink by stimulating the neurons that normally become active when a mouse is actually thirsty.


Explore further

Had enough water? Brain's thirst centers make a gut check

More information: W.E. Allen el al., "Thirst regulates motivated behavior through modulation of brainwide neural population dynamics," Science (2019). science.sciencemag.org/cgi/doi … 1126/science.aav3932
Journal information: Science

© 2019 Science X Network

Citation: Study shows thousands of neurons becoming active during thirst and quench cycle (2019, April 9) retrieved 19 June 2019 from https://medicalxpress.com/news/2019-04-thousands-neurons-thirst-quench.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
428 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more