Vitamin D deficiency tied to gestational diabetes risk

Vitamin D deficiency tied to gestational diabetes risk

(HealthDay)—Maternal vitamin D deficiency, as early as the first trimester of pregnancy, is associated with an increased risk for gestational diabetes mellitus (GDM), according to a study recently published in Diabetes, Obesity and Metabolism.

Jin Xia, from the Richard M. Fairbanks School of Public Health at Indiana University in Indianapolis, and colleagues used data from the Fetal Growth Studies-Singleton Cohort to prospectively investigate the between vitamin D status during early to midpregnancy and GDM risk. Plasma levels of 25-hydroxyvitamin D2 and D3 and vitamin D binding protein were measured at gestational weeks 10 to 14, 15 to 26, 23 to 31, and 33 to 39 in 107 women with GDM and 214 controls.

The researchers observed a threshold effect for the relationship between vitamin D biomarkers and GDM risk. At 10 to 14 gestational weeks, vitamin D deficiency (<50 nmol/L) was associated with a 2.82-fold increased risk for GDM. Among women with persistent vitamin D deficiency at 10 to 14 and 15 to 26 weeks of gestation, there was a 4.46-fold elevated risk for GDM versus women who were persistently nondeficient.

"Assessment of vitamin D status in early pregnancy may be clinically important and valuable for improving risk stratification and developing effective interventions for the primary prevention of GDM," the authors write.


Explore further

Increased first-trimester HbA1c predicts gestational diabetes

More information: Abstract/Full Text

Copyright © 2019 HealthDay. All rights reserved.

Citation: Vitamin D deficiency tied to gestational diabetes risk (2019, May 22) retrieved 15 September 2019 from https://medicalxpress.com/news/2019-05-vitamin-d-deficiency-tied-gestational.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
9 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more