Buzz off: breakthrough technique eradicates mosquitoes

Anopheles gambiae mosquito, feeding on blood. Credit: James Gathany, Centers for Disease Control and Prevention
A breakthrough technique harnessing two methods to target disease-carrying mosquitoes was able to effectively eradicate buzzing biters in two test sites in China, according to research published on Thursday.

The targeted are a type that is particularly difficult to control called Aedes albopictus—more popularly known as the Asian tiger mosquito—which are a major vector for diseases including Zika and dengue.

The study "demonstrates the potential of a potent new tool", wrote Peter Armbruster, a professor at Georgetown University's department of biology, in a review of the work.

Researchers harnessed two population control methods: the use of radiation—which effectively sterilises mosquitoes—and a called Wolbachia that leaves mosquito eggs dead on arrival.

They conducted a two-year trial at two sites on river islands in Guangzhou, where Asian tiger mosquitoes are to blame for the highest dengue transmission rate in China.

The results were "remarkable", wrote Armbruster: the number of hatched mosquitoes eggs plunged by 94 percent, with not a single viable egg recorded for up to 13 weeks in some cases.

And the average number of female mosquitoes—which transmit disease to humans when they bite—caught by traps fell by between 83 and 94 percent.

In some cases, none were detected at all for up to six weeks.

The results were also borne out by a decline of nearly 97 percent in bites suffered by locals—which in turn shifted attitudes among residents, who were initially sceptical of the project's plan to release more mosquitoes into the local area.

Radiation and bacteria

The research builds on two existing methods: radiation-based sterile insect technique (SIT) and incompatible insect technique (IIT).

SIT works by releasing radiation-sterilised male mosquitoes into an environment to mate with wild female mosquitoes, reducing the size of the population over time as females fail to reproduce.

But irradiation of male mosquitoes tends to reduce both their mating competitiveness and their survival rates, undermining the technique's effectiveness.

The IIT method involves a bacteria called Wolbachia. When males infected with it mate with female mosquitoes that aren't infected, their eggs don't hatch.

The technique doesn't work if the female mosquitoes are infected with the same Wolbachia strain, and successful mating by mosquitoes that both carry the bacteria undermines the technique by producing more female mosquitoes infected with Wolbachia that are resistant to the process.

Preventing the release of Wolbachia-infected is difficult, with sex-sorting techniques usually resulting in a "female contamination rate" of about 0.3 percent.

To overcome that, researchers decided to subject their Wolbachia-infected lab-reared mosquitoes to low-level irradiation, which rendered the females sterile but left the males able to reproduce.

This allowed the team to avoid the onerous sex-screening process and meant they could release significantly more mosquitoes at a time: in some cases more than 160,000 male mosquitoes per hectare, per week.

'Striking results'

Lead researcher Zhiyong Xi, a professor at Michigan State University's department of Microbiology and Molecular Genetics, compared the technique to "producing insecticide".

"Our goal is to use this technique to build a protected area that is disease vector-free," Xi told AFP.

Armbruster, in a review commissioned by the journal Nature that published the research on Thursday, said the study produced "striking results".

That the trial "almost eliminated notoriously difficult-to-control vector mosquitoes from the test sites is remarkable," he wrote.

The results weren't a universal success—populations in areas with more traffic, near construction or roads, shrank less than those in isolated zones, likely as mosquitoes migrated in from elsewhere.

But Xi said the still holds promise if "natural barriers" like highways are used to limit the arrivals of outside mosquitoes.

And he said it could be used against mosquitoes that carry disease, including malaria.

The next steps will involve developing a "highly effective and practical release strategy" suited for urban settings," he said.

Explore further

Combating mosquito-borne diseases with bacteria

More information: Incompatible and sterile insect techniques combined eliminate mosquitoes, Nature (2019). DOI: 10.1038/s41586-019-1407-9
Journal information: Nature

© 2019 AFP

Citation: Buzz off: breakthrough technique eradicates mosquitoes (2019, July 17) retrieved 15 October 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Jul 18, 2019
Where's PETA?
Where's the Climate Change folks?

Jul 18, 2019
RBonsweenie2 What does PETA or "the Climate Change folks" have to do with this? Frankly I don't see the connection. Would they be against it you mean?

China is destroying the ecosystem and its intricate food chain:

Damselflies, et al

will all become endangered right about the time the planet is destroyed 11.2 years from now. ~ Source Alexandria Ocasio-Cortez, self-proclaimed climate 'scientists', and their faithful, dogmatic zealots.

Jul 19, 2019
Eliminating a layer of the food chain. Great idea. This has nothing to do with climate change, and nothing to do with common sense.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more