Rotavirus cell invasion triggers a cacophony of calcium signals

Rotavirus cell invasion triggers a cacophony of calcium signals
Dr. Joseph Hyser Credit: Baylor College of Medicine

To successfully set off disease, rotavirus, a virus that causes severe diarrhea and vomiting in children around the world, must invade cells of the gastrointestinal track and trigger a surge of calcium inside the cells. How this surge occurs has not been clarified, but a report in the journal Scientific Reports released today shows in cinematic detail the dynamic changes in calcium that follow rotavirus invasion.

Using time-lapsing imaging and other experimental approaches, researchers at Baylor College of Medicine and Indiana University reveal that rotavirus induces hundreds of discrete and highly dynamic calcium spikes that increase during peak infection. The calcium spikes can be attenuated by genetically knocking down rotavirus protein NSP4, which is known to disturb calcium balance within cells. The spikes originate from calcium released from the , a specialized structure within cells, into the cytoplasm of the cell.

The study's findings open new ways to better understand what the virus does to cause disease.


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More information: Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum, Scientific Reports (2019). DOI: 10.1038/s41598-019-46856-8
Journal information: Scientific Reports

Citation: Rotavirus cell invasion triggers a cacophony of calcium signals (2019, July 25) retrieved 22 November 2019 from https://medicalxpress.com/news/2019-07-rotavirus-cell-invasion-triggers-cacophony.html
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