Serum IL-35 levels tied to bone loss with rheumatoid arthritis

Serum IL-35 levels tied to bone loss with rheumatoid arthritis

Serum interleukin (IL)-35 levels are associated with bone loss and may represent a novel therapeutic target for postmenopausal women with rheumatoid arthritis (RA), according to a study published online Aug. 26 in Mediators of Inflammation.

Yuxuan Li, from the First Affiliated Hospital of China Medical University in Shenyang, and colleagues explored the correlations between IL-35 levels and bone loss in postmenopausal women, including 76 with RA and 53 healthy controls. Additionally, dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at lumbar spine 1 to 4 and at total hip.

The researchers found that serum IL-35 levels were increased in RA patients compared with healthy controls. Additionally, serum IL-35 level positively correlated with BMD and 25-hydroxyvitamin D3 level and negatively correlated with β-isomerised carboxy-terminal cross-linking telopeptide of type I collagen in postmenopausal women with RA. Women with higher alkaline phosphatase (ALP) levels had higher serum IL-35 levels than those in the normal ALP group.

"IL-35, an important anti-inflammatory cytokine, may participate in the pathogenesis of in with RA," the authors write.


Explore further

Family history of diabetes linked to increased bone mineral density

More information: Abstract/Full Text

Copyright © 2019 HealthDay. All rights reserved.

Citation: Serum IL-35 levels tied to bone loss with rheumatoid arthritis (2019, September 27) retrieved 16 November 2019 from https://medicalxpress.com/news/2019-09-serum-il-tied-bone-loss.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
4 shares

Feedback to editors

User comments