Long-term blood pressure variation and risk of dementia

Long-term blood pressure variation and risk of dementia
In a new research study published in the open access journal PLOS Medicine, Albert Hofman and colleagues at Erasmus MC University Medical Center, Rotterdam, the Netherlands and Harvard T.H. Chan School of Public Health, Boston, United States report that people who experienced substantial changes in blood pressure over the long term were at greater risk of dementia than those who did not. Credit: rawpixel, Pixabay

In a new research study published in the open access journal PLOS Medicine, Albert Hofman and colleagues at Erasmus MC University Medical Center, Rotterdam, the Netherlands and Harvard T.H. Chan School of Public Health, Boston, United States report that people who experienced substantial changes in blood pressure over the long term were at greater risk of dementia than those who did not.

The authors studied 5,273 people in Rotterdam, the Netherlands at a mean age of 67.6 years, who were free of dementia at the beginning of the study and were followed-up for 14.6 years. After adjustment for age, sex and other factors that could affect the findings, at 15 years people in the highest quintile, who exhibited an increase in systolic blood pressure, had a hazard ratio of 3.31 (95% Confidence Interval 2.11-5.18) for risk of dementia as compared with those in the quintile with the least change in blood pressure. Those in the lowest quintile, with the largest fall in , had a hazard ratio of 2.20 (95% CI 1.33-3.63) for dementia risk, again compared to those with the least change. Variations in both systolic and led to similar findings.

Assuming that Hofman and colleagues' findings reflect a between blood pressure variation and dementia, the authors note a "potential to prevent dementia through targeting blood pressure variability above and beyond the mere control of conventional limits", and note that the association observed over a long time period implies that interventions should be implemented earlier in life to yield potential benefits.


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More information: Yuan Ma et al, Variation in blood pressure and long-term risk of dementia: A population-based cohort study, PLOS Medicine (2019). DOI: 10.1371/journal.pmed.1002933
Journal information: PLoS Medicine

Citation: Long-term blood pressure variation and risk of dementia (2019, November 13) retrieved 11 December 2019 from https://medicalxpress.com/news/2019-11-long-term-blood-pressure-variation-dementia.html
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