Study finds no harm for newborns whose mothers were treated with magnesium sulphate during pregnancy

Peace of mind for expectant parents
Credit: AI-generated image (disclaimer)

A team led by Adelaide-based researchers has taken an important step towards validating the safety of intravenous magnesium sulphate as a treatment during pregnancy.

Lead author Emily Shepherd, a Ph.D. candidate with the University of Adelaide and SAHMRI Women & Kids theme, says these findings will give comfort to parents and doctors amid widespread and increasing use of magnesium sulphate in obstetric practice.

"Until now there has been speculation this beneficial treatment could unintentionally harm the , but it's been unclear either way," Mrs Shepherd says.

"Our team undertook a that analyzed almost 200 studies, including 40 randomized trials, and found no clear differences in harm for newborns whose mothers were treated with magnesium sulphate during pregnancy and those whose mothers received no treatment or a placebo."

The findings were published today in PLOS Medicine.

Magnesium sulphate has a long history of use for women with pre-eclampsia or eclampsia. In the past decade it has been introduced as a treatment for who are likely to have a very to reduce the chances of their baby developing .

"Around 3500 births are very premature, at less than 30 completed weeks of pregnancy, every year in Australia," Mrs Shepherd says.

"Our findings support the continued use of magnesium sulphate as a safe treatment for these women, as well as for pregnant women suffering from pre-eclampsia or eclampsia."

Senior author Professor Caroline Crowther's team is continuing to research use of magnesium sulphate during pregnancy, including whether can be effective for cerebral palsy prevention for later preterm births up to 34 completed weeks of pregnancy.

"We are extremely grateful to the Cerebral Palsy Alliance Australia who has supported this important work," Professor Crowther said.

More information: Emily Shepherd et al. Antenatal magnesium sulphate and adverse neonatal outcomes: A systematic review and meta-analysis, PLOS Medicine (2019). DOI: 10.1371/journal.pmed.1002988

Journal information: PLoS Medicine
Provided by South Australian Health and Medical Research Institute (SAHMRI)
Citation: Study finds no harm for newborns whose mothers were treated with magnesium sulphate during pregnancy (2019, December 9) retrieved 22 June 2024 from https://medicalxpress.com/news/2019-12-newborns-mothers-magnesium-sulphate-pregnancy.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Study reveals level of magnesium sulfate to prevent cerebral palsy in preterm infants

4 shares

Feedback to editors