New automated method developed for corneal nerve fiber tortuosity analysis

New automated method developed for corneal nerve fiber tortuosity analysis
Typical example of the exponential curvature estimation applied to corneal nerve fiber images. Credit: CNITECH

The Intelligent Medical Imaging (iMED) Group at the Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering (CNITECH) of the Chinese Academy of Sciences proposed a fully automated method for image-level corneal nerve fiber tortuosity estimation, contributing to the examination and diagnosis of eye-related diseases. The study was published in IEEE Transactions on Medical Imaging.

Existing suggests that the morphological changes in anatomical curvilinear structures, such as blood vessels or nerve fibers, are closely linked to various diseases. Tortuosity is one of the most significant biomarkers reflecting variations in corneal nerve fibers, serving as a significant clinical parameter to assess eye-related diseases, like hypertensive retinopathy and diabetic neuropathy.

However, there is no universally-accepted standard measure of tortuosity. Meanwhile, traditional automated tortuosity relies heavily on the quality of segmentation results, which may generate errors due to poor imaging quality and low image resolution.

To address this issue, the research group proposed a new automated method for image-level tortuosity estimation, comprising image enhancement, exponential curvature estimation, and tortuosity level classification. They proposed an extended noise-constrained Retinex model to enhance corneal confocal microscopy (CCM) images, which was able to correct imbalanced illumination, so as to improve image contrast. By virtue of the exponential curvature estimation in the 3-D space of positions and orientations, they were able to directly measure curvature based on the enhanced images, rather than relying on the explicit segmentation and skeletonization steps in a conventional pipeline.

The proposed method has been applied to two corneal nerve microscopy datasets for the tortuosity estimation. The experimental results demonstrated that it performs better than several conventional state-of-the-art ones. In addition, the group constructed a new dataset including 403 corneal microscopic images with their tortuosity level annotated, and this dataset has been released for , paving the way for other researchers in conducting further studies on relevant topics.

More information: Yitian Zhao et al. Automated Tortuosity Analysis of Nerve Fibers in Corneal Confocal Microscopy, IEEE Transactions on Medical Imaging (2020). DOI: 10.1109/TMI.2020.2974499

Citation: New automated method developed for corneal nerve fiber tortuosity analysis (2020, March 10) retrieved 27 February 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Reduced corneal nerve fiber density in patients with HIV


Feedback to editors