Like patching a flat tire: New fix heals herniated discs

Like patching a flat tire: New fix heals herniated discs
Multiphoton images showing the alignment of collagen in an intervertebral disc in a sheep treated with the collagen patch. Credit: S.R. Sloan et al., Science Translational Medicine (2020)

A new two-step technique to repair herniated discs uses hyaluronic acid gel to re-inflate the disc and collagen gel to seal the hole, essentially repairing ruptured discs like you'd repair a flat tire.

After a rupture, a jelly-like material leaks out of a , causing inflammation and pain. The injury is usually treated one of two ways: a surgeon sews up the hole, leaving the disc deflated; or the disc is refilled with a replacement material, which doesn't prevent repeat leakages. Each approach on its own isn't always effective.

A collaboration led by Cornell University professor Lawrence Bonassar combined these two methods into a new two-step technique that results in a "patched" disc that maintains mechanical function and won't collapse or deteriorate.

"This is really a new avenue and a whole new approach to treating people who have herniated ," Bonassar said.

"We now have potentially a new option for them, other than walking around with a big hole in their and hoping that it doesn't re-herniate or continue to degenerate. And we can fully restore the mechanical competence of the disc."

Bonassar's research group seeks engineering-based solutions for . Over the last decade, the group has developed a collagen gel that incorporates riboflavin, a photoactive vitamin B derivative. Instead of sewing up a ruptured disc, the researchers can patch it by applying their gel and shining light on it to activate the riboflavin.

The resulting chemical reaction causes fibers in the collagen to bond together and the thick gel stiffens into a solid. Most importantly, the gel provides a more fertile ground for cells to grow new tissue, sealing the defect better than any suture could.

The technique only takes five or 10 minutes and can be applied in conjunction with a discectomy, the hourlong procedure by which the leaked nucleus pulposus is removed from the nerve root. The technique could be used to address other types of disc degeneration, or integrated into other spinal procedures and therapies.

The paper, "Combined Nucleus Pulposus Augmentation and Annulus Fibrosus Repair Prevents Acute Intervertebral Disc Degeneration after Discectomy," published in Science Translational Medicine.


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More information: S.R. Sloan el al., "Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy," Science Translational Medicine (2020). stm.sciencemag.org/lookup/doi/ … scitranslmed.aay2380
Journal information: Science Translational Medicine

Provided by Cornell University
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