Study eyes partially lost essential genes as possible targets in cancer

Study eyes partially lost essential genes as possible targets in cancer
Credit: Susanna M. Hamilton, Broad Communications

Genes that perform critical but mundane tasks within cells—such as generating energy or eliminating waste—haven't traditionally been considered prime targets for cancer therapy. A new study led by Caitlin Nichols, Brenton Paolella, and associate member Rameen Beroukhim of the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute suggests they should be.

The study—published in Nature Communications, and relying in part on data from the Cancer Cell Line Encyclopedia, the Cancer Dependency Map project, The Cancer Genome Atlas (or TCGA), and the Exome Aggregation Consortium (now gnomAD) database, among others—identified more than 1,200 "" that could serve as targets for future therapies. Unlike cancer genes, whose malfunction causes cells to grow out of control, essential genes are normal genes that carry out the basic activities of cell life. Because cancer cells often have only one copy of these genes, whereas normal cells have two, drugs that target a single copy could be lethal to while leaving normal cells fully functional.

In the video presentation below, Nichols describes the research that led to the identification of genes in which this vulnerability can be exploited. A drug targeting just one such vulnerability could benefit more than 18,000 patients with cancer in the US each year, she says.

Credit: Harvard Graduate School of Arts and Sciences

More information: Caitlin A. Nichols et al. Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities, Nature Communications (2020). DOI: 10.1038/s41467-020-16399-y

Journal information: Nature Communications
Citation: Study eyes partially lost essential genes as possible targets in cancer (2020, May 25) retrieved 25 April 2024 from
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