Residual shunt after patent foramen ovale closure linked to higher risk for stroke

Residual shunt after PFO closure linked to higher risk for stroke

The presence of a residual shunt after patent foramen ovale (PFO) closure is associated with an increased risk for recurrent stroke or transient ischemic attack (TIA), according to a study published online May 12 in the Annals of Internal Medicine.

Wenjun Deng, Ph.D., from Massachusetts General Hospital in Boston, and colleagues examined the long-term association of a residual with recurrent neurologic events after percutaneous PFO closure. A total of 1,078 patients with PFO-attributable cryptogenic stroke undergoing percutaneous PFO closure were followed for up to 11 years.

The researchers found that the presence of a residual shunt versus complete closure was associated with an increased incidence of or TIA (2.32 versus 0.75 events per 100 patient-years; hazard ratio, 3.05; 95 percent interval, 1.65 to 5.62; P < 0.001). After adjustment for covariates, including age; study period; device; presence of atrial septal aneurysm, hypertension, hyperlipidemia, diabetes, hypercoagulability, or hypermobile septum; and medication use, the results remained robust (hazard ratio, 3.01; 95 percent confidence interval, 1.59 to 5.69; P < 0.001). Moderate or large residual shunts were associated with an for or TIA recurrence (hazard ratio, 4.50; 95 percent confidence interval, 2.20 to 9.20; P < 0.001), while the result was not statistically significant for small residual shunts (hazard ratio, 2.02; 95 percent confidence interval, 0.87 to 4.69; P = 0.102).

"We suggest that patients with a moderate or large residual shunt be followed long term with multidisciplinary care," the authors write.

One author disclosed financial ties to the pharmaceutical and medical device industries.


Explore further

Vitamin D, omega-3 do not cut heart failure hospitalization

More information: Abstract/Full Text
Editorial
Journal information: Annals of Internal Medicine

Copyright © 2020 HealthDay. All rights reserved.

Citation: Residual shunt after patent foramen ovale closure linked to higher risk for stroke (2020, May 12) retrieved 24 November 2020 from https://medicalxpress.com/news/2020-05-residual-shunt-patent-foramen-ovale.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments