Nephrogenic systemic fibrosis rare with newer GBCA exposure

Nephrogenic systemic fibrosis rare with newer GBCA exposure

(HealthDay)—The occurrence of nephrogenic systemic fibrosis (NSF) appears to be rare after exposure to newer gadolinium-based contrast agents (GBCA), according to a review published online June 23 in the Annals of Internal Medicine.

Joseph Lunyera, M.B.Ch.B., from the Duke University School of Medicine in Durham, North Carolina, and colleagues synthesized evidence about NSF risk with newer versus older GBCAs. Twenty studies assessed NSF risk after exposure to newer GBCAs and 12 compared risk between newer and older GBCAs.

The researchers found no cases of NSF developed among 83,291 patients exposed to newer GBCAs. In the 12 studies that compared risk for newer and older GBCAs, with 118,844 patients, 37 NSF cases developed after exposure to older GBCAs, while there were four cases (three confounded) after exposure to newer GBCAs. For patients with or those at risk for (CKD), data were scant.

"The occurrence of NSF after exposure to newer linear or macrocyclic GBCAs was very rare," the authors write. "However, considering the scarcity of data about the use of newer and seemingly safer GBCAs among with advanced CKD, CKD risk factors, or acute kidney injury, further investigations in these populations are warranted."

Explore further

New contrast agent could make MRIs safer

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Annals of Internal Medicine

Copyright © 2020 HealthDay. All rights reserved.

Citation: Nephrogenic systemic fibrosis rare with newer GBCA exposure (2020, June 23) retrieved 10 July 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments