Combination asthma medication is over-prescribed to Australian children—but dispensing patterns are improving

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Australian children—preschoolers in particular—are being inappropriately prescribed fixed dose combination (FDC) asthma medication, a UNSW Sydney big data study on asthma dispensing patterns has shown.

This type of inhaler contains a combination of two medicines and should only be prescribed when inhalers with a single preventative medicine (called inhaled corticosteroid, or ICS) are ineffective in controlling asthma symptoms.

But according to the findings, 88 percent of FDC inhalers dispensed to and adolescents aged between one and 18 are prescribed as a first line of controller therapy.

"Most alarmingly, in our study cohort—which looked at 10 percent of the Australian population—we found that around 3,500 Australian children aged five or under are dispensed FDC inhalers annually," says respiratory epidemiologist Dr. Nusrat Homaira, lead author of the big data study and senior lecturer in paediatrics at UNSW Medicine.

"According to national asthma guidelines, children aged five or under shouldn't be prescribed FDC inhalers at all."

The findings, published today in the International Journal of Environmental Research and Public Health, come two years after the Pharmaceutical Benefits Advisory Committee (PBAC) made recommendations that FDC dispensing patterns in children were 'unacceptably high' and needed to change.

According to the Australian Asthma Handbook, created by the National Asthma Council, children and adolescents aged between six and 18 should only be prescribed FDCs after trying an initial therapy with ICS.

This 'step-up' approach to asthma management aims to minimise potential risks of prescribing the medication to young children.

"There is lack of evidence suggesting benefit of FDC in children—especially in preschoolers," says Dr. Homaira.

"Some data suggests it may even increase risk of asthma exacerbation and result in development of tolerance to asthma relievers in young children."

The UNSW medical researchers used a set of routinely collected dispensing data from the Pharmaceutical Benefits Scheme (PBS), provided by Services Australia.

The randomised data set included almost 36,000 children and adolescents aged 1−18 years who were dispensed at least one FDC between January 2013 and December 2018. Of this sample, more than 31,000 didn't have a preceding ICS prescription.

The study is the first data analysis on national asthma dispensing patterns since 2014.

Dr. Homaira stresses that despite these high dispensing rates, asthma dispensing patterns are improving.

"Overall, FDC dispensing in children—and more importantly, FDC dispensing without a preceding ICS—is declining in Australia," she says.

"In 2013, around 15 in every 1000 children were prescribed an FDC inhaler. By 2018, this dropped to around seven in every 1000 children.

"More work needs to be done, but we are moving in the right direction."

A step-up approach

There are two main types of asthma medications: reliever medication, which help manage the symptoms of asthma (commonly known as blue puffers), and controller medication, which help prevent and control asthma attacks.

Both FDC and ICS belong to the second group of controller medicines, which generally come in the form of puffers. They include corticosteroid, an anti-inflammatory medication, but FDC also includes a long-acting muscle relaxant.

"FDCs are one of the most expensive asthma controller medicines on the market," says Dr. Homaira.

"The overall cost of FDC prescriptions to children in our study was 7.8 million dollars. This cost was split between the government, who paid 4.5 million, and the patients, who paid 3.3 million."

These costs would have been lower if children were first prescribed the more appropriate ICS medication, she explains.

"It's important that , like the Australian Asthma Handbook, are properly adhered to by medical practitioners," says Dr. Homaira. "Clinical guidelines standardise clinical care, reduce the waste of health resources, and improve the value of healthcare.

"We need to improve ' awareness of asthma guidelines and appropriate prescribing practices—especially in children aged under five."

The importance of health data

COVID-19 has highlighted the importance of collecting health data, says Dr. Homaira. The pandemic is also an example of how health data can influence .

She is hopeful that the FDC findings can help monitor changes to asthma dispensing policies over time.

"Australia is in such a unique position because we have so many administrative health data sets," Dr. Homaira explains.

"While administrative data can't always answer the granular questions, like why so many practitioners are prescribing FDCs to children, it can highlight the problem.

"Data gives the aerial view—a snapshot of what's happening in Australian healthcare. Once you have this snapshot, you can dig into the details and potentially advocate for policy changes."


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More information: Nusrat Homaira et al. Dispensing Practices of Fixed Dose Combination Controller Therapy for Asthma in Australian Children and Adolescents, International Journal of Environmental Research and Public Health (2020). DOI: 10.3390/ijerph17165645
Citation: Combination asthma medication is over-prescribed to Australian children—but dispensing patterns are improving (2020, August 6) retrieved 4 December 2020 from https://medicalxpress.com/news/2020-08-combination-asthma-medication-over-prescribed-australian.html
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