Longer bisphosphonate use may up atypical femur fracture risk

Longer bisphosphonate use may up atypical femur fracture risk

(HealthDay)—Longer duration of bisphosphonate use is associated with an increased risk for atypical femur fracture, according to a study published in the Aug. 20 issue of the New England Journal of Medicine.

Dennis M. Black, Ph.D., from the University of California in San Francisco, and colleagues studied women aged 50 years or older who received bisphosphonates. Women were followed from Jan. 1, 2007, to Nov. 30, 2017, for the primary outcome of atypical femur fracture.

The researchers found that 277 occurred among 196,129 women. There was an increase in the risk for atypical fracture with a longer duration of bisphosphonate use after multivariable adjustment, with hazard ratios of 8.86 and 43.51 for three years to less than five years and for eight years or more, respectively, compared with less than three months. Race, height, weight, and glucocorticoid use were also risk factors. Discontinuation of bisphosphonate use was associated with a in atypical fracture risk. During one to 10 years of bisphosphonate use, decreases in the risk for osteoporotic and hip fractures outweighed the for atypical fractures among whites, but less so among Asians. In whites, 149 hip fractures were prevented and two bisphosphonate-associated atypical fractures occurred after three years compared with 91 and eight fractures, respectively, in Asians.

"These results in a diverse cohort contribute to existing but limited evidence about the risks and benefits of treatment in individual patients or populations," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further

Time for balance? Preventing atypical femoral fractures related to bisphosphonates

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: New England Journal of Medicine

Copyright © 2020 HealthDay. All rights reserved.

Citation: Longer bisphosphonate use may up atypical femur fracture risk (2020, August 20) retrieved 1 March 2021 from https://medicalxpress.com/news/2020-08-longer-bisphosphonate-atypical-femur-fracture.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments