New drug that can prevent drug resistance and adverse effects

New drug that can prevent the drug resistance and adverse effects
This cancer cell specific anti-cancer drug precursor (SMAC-FRG-DOX) formed itself by hydrophobic interaction within the molecule without the use of additional polymers and drug carriers, and is optionally activated by cathesin B, an overexpressed enzyme within the cancer cell, releasing SMAC and Doxorubicin simultaneously. Credit: Korea Institue of Science and Technology(KIST)

Among diverse treatment methods developed to effectively treat cancer, chemotherapy using anticancer agents has been proven especially effective in many clinical applications. Above all, it is more affordable than other treatment methods and is effective against most types of cancer, which is why it is the most common approach to treat disease.

However, in significantly reduces the effectiveness and sensitivity of chemotherapy, leading to recurrence and treatment failure. Cancer cells inherently have resistance against , and even the ones that are highly responsive to chemotherapy may develop resistance in the course of treatment.

A research team in Korea is garnering attention for having developed an anticancer that could potentially prevent drug resistance. The Korea Institute of Science and Technology (KIST) announced that a team of researchers led by Dr. Kwang-meyung Kim at the Theragnosis research center successfully developed a cancer-specific anticancer drug precursor that can prevent drug resistance.

The research team came up with a new drug by conjugating a drug that inhibits resistance against (SMAC) and an anticancer agent (Doxorubicin). The resulting drug remains inactive in the body until it encounters a cancer cell and reacts with an enzyme (cathepsin B) that is overexpressed in cancer cells. In cancer cells, it specifically releases the anticancer agent along with the drug-resistance inhibitor to effectively treat cancers without the development of drug resistance.

New drug that can prevent the drug resistance and adverse effects
Metastatic lung cancer growth was observed through whole-body bioluminescence imaging via IVIS Lumina Series III at the indicated time points after treatment of free DOX, DOX/SMAC combination or DD-NPs once every three days. Credit: Korea Institue of Science and Technology(KIST)

As a result, it can inhibit not only the inherent drug resistance of cancer cells as well as the aquired drug resistance that cancer cells can develop during chemotherapy. This will make it possible to administer without any potential recurrence or treatment failure.

Also, cathepsin B, the enzyme that allows the drug to react with cancer cells, is produced in relatively small amounts in . As a result, the drug-drug nanoparticles remain inactive and they do not release the drug in normal cells, which will reduce the side effects associated with conventional chemotherapy.

Dr. Kim from KIST said, "The cancer-specific drug-drug nanoparticles effectively inhibit drug resistance that leads to treatment failures in conventional chemotherapy, and at the same time, reduces toxicity in normal cells, so it is expected that it will be possible to use it as a new anticancer agent that can prevent drug resistance and adverse effects."

More information: Man Kyu Shim et al, Cancer-specific drug-drug nanoparticles of pro-apoptotic and cathepsin B-cleavable peptide-conjugated doxorubicin for drug-resistant cancer therapy, Biomaterials (2020). DOI: 10.1016/J.BIOMATERIALS.2020.120347

Journal information: Biomaterials

Provided by National Research Council of Science & Technology
Citation: New drug that can prevent drug resistance and adverse effects (2020, October 21) retrieved 21 September 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Molecule secreted by cancer-associated fibroblasts promotes anticancer drug resistance


Feedback to editors