Exposure to suboptimal doses of antimalarial drugs could increase malaria transmission

Exposure to suboptimal doses of antimalarial drugs could, under certain circumstances, increase mala
Parasite exposure to suboptimal doses of artemisinin can lead to a considerable increase in sexual conversion rates and gametocyte numbers. This effect depends on the stage of the parasite's cycle (it was observed with trophozoites but not with the previous ring stage). Credit: ISGlobal

Exposure to suboptimal doses of the antiparasitic drug artemisinin could increase the sexual conversion rate of the malaria parasite Plasmodium falciparum, thereby increasing the probability of transmission, according to a study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by 'la Caixa' Foundation. The findings, published in eLife, may have public health implications, particularly in the context of mass antimalarial drug administration campaigns.

The malaria parasite P. falciparum replicates asexually in human blood every 48 hours, causing the typical clinical symptoms of the disease. At each replication cycle, a small number of take a different pathway: that of sexual to generate gametocytes. This sexual form of the parasite is the only one that can be transmitted to the mosquito. Sexual conversion is a highly regulated process, since the parasite needs to maintain a balance between asexual replication within the host and transmission between hosts. "From an evolutionary point of view, the parasite's capacity to adjust its sexual conversion rate in response to the host's conditions is clearly advantageous," explains Alfred Cortés, ICREA researcher at ISGlobal and study coordinator. One factor that clearly decreases the parasite's 'comfort' within the host is exposure to parasite-killing drugs.

In order to determine whether artemisinin (the first-choice for treating malaria falciparum) or artemisinin-related drugs can affect the parasite's sexual conversion rate, Cortés and his team used a transgenic parasite line that allows them to quantify sexual conversion in a dish, under different experimental conditions. They found that parasite exposure to artemisinin can lead to a considerable increase in sexual conversion rates and gametocyte numbers. But this effect was only seen with suboptimal drug doses and depended on the stage of the parasite's cycle (it was observed with trophozoites but not with the previous ring stage).

"Our results show there is a complex interaction between and sexual conversion, which depends on the parasite stage, its metabolic state and drug doses," says Harvie Portugaliza, first author of the study.

"It is possible that patients in which most parasites are at the trophozoite stage at the time of treatment may have a peak in gametocyte production ten days later (the time required for their maturation), if the drug did not manage to kill all the parasites," says Cortés. Exposure to suboptimal drug concentrations could result from using poor quality drugs or poor adherence to the treatment. Currently, the team led by Cortés is performing to determine whether sexual conversion is indeed higher among patients treated with artemisinin.


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More information: Harvie P Portugaliza et al, Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently, eLife (2020). DOI: 10.7554/eLife.60058
Journal information: eLife

Citation: Exposure to suboptimal doses of antimalarial drugs could increase malaria transmission (2020, October 28) retrieved 28 September 2021 from https://medicalxpress.com/news/2020-10-exposure-suboptimal-doses-antimalarial-drugs.html
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