Hyperglycemia, hypoglycemia linked to poor outcomes in COVID-19

Hyperglycemia, hypoglycemia linked to poor outcomes in COVID-19

(HealthDay)—For patients with COVID-19, hyperglycemia and hypoglycemia are associated with poor outcomes, according to a study published online Dec. 15 in Diabetes Care.

David C. Klonoff, M.D., from the Mills-Peninsula Medical Center in San Mateo, California, and colleagues analyzed pooled data from the Glytec for 1,544 with COVID-19 from 91 hospitals in 12 states. Patients were stratified according to achieved mean glucose category during days 2 to 3 in non- (ICU) patients or on day 2 in ICU patients. The authors examined the association between glucose category and .

The researchers found that 18.1 percent of patients died in the hospital. Among non-ICU patients, compared with <7.77 mmol/L, severe hyperglycemia (>13.88 mmol/L) on days 2 to 3 was independently associated with high mortality (adjusted hazard ratio, 7.17). This association was not significant for admission glucose. In patients admitted directly to the ICU, increased mortality was seen in association with severe hyperglycemia on admission (adjusted hazard ratio, 3.14). This association was not significant on day 2. There was also an association seen for hypoglycemia and increased mortality (odds ratio, 2.2).

"We found that severe hyperglycemia early in the course of hospitalization in patients with COVID-19 admitted to a non-ICU setting was associated with a sevenfold increase in mortality risk," the authors write. "Our results suggest patients with COVID-19 should promptly receive treatment to improve glycemic control."

Several authors disclosed financial ties to Glytec.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: Diabetes Care

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Citation: Hyperglycemia, hypoglycemia linked to poor outcomes in COVID-19 (2020, December 16) retrieved 8 December 2023 from https://medicalxpress.com/news/2020-12-hyperglycemia-hypoglycemia-linked-poor-outcomes.html
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