Aspirin use may decrease ventilation, ICU admission and death in COVID-19 patients

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George Washington University researchers found low dose aspirin may reduce the need for mechanical ventilation, ICU admission and in-hospital mortality in hospitalized COVID-19 patients. Final results indicating the lung protective effects of aspirin were published today in Anesthesia & Analgesia.

"As we learned about the connection between blood clots and COVID-19, we knew that aspirin—used to prevent stroke and —could be important for COVID-19 patients," Jonathan Chow, MD, assistant professor of anesthesiology and critical care medicine and director of the Critical Care Anesthesiology Fellowship at the GW School of Medicine and Health Sciences, said. "Our research found an association between and decreased severity of COVID-19 and death."

Over 400 patients admitted from March to July 2020 to hospitals around the United States, including those at GW Hospital, the University of Maryland Medical Center, Wake Forest Baptist Medical Center and Northeast Georgia Health System, were included in the study. After adjusting for demographics and comorbidities, aspirin use was associated with a decreased risk of (44% reduction), ICU admission (43% reduction), and in- (47% reduction). There were no differences in major bleeding or overt thrombosis between aspirin users and non-aspirin users.

Preliminary findings were first published as a preprint in fall 2020. Since then, other studies have confirmed the impact aspirin can have on both preventing infection and reducing risk for severe COVID-19 and death. Chow hopes that this study leads to more research on whether a causal relationship exists between aspirin use and reduced lung injury in COVID-19 patients.

"Aspirin is low cost, easily accessible and millions are already using it to treat their health conditions," said Chow. "Finding this association is a huge win for those looking to reduce risk from some of the most devastating effects of COVID-19."


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More information: Jonathan H. Chow et al, Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019, Anesthesia & Analgesia (2020). DOI: 10.1213/ANE.0000000000005292
Journal information: Anesthesia & Analgesia

Citation: Aspirin use may decrease ventilation, ICU admission and death in COVID-19 patients (2021, March 17) retrieved 27 July 2021 from https://medicalxpress.com/news/2021-03-aspirin-decrease-ventilation-icu-admission.html
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