Erectile dysfunction could be prevented by blocking endothelin-1

Erectile dysfunction could be prevented by blocking endothelin-1
Credit: Nick Youngson CC BY-SA 3.0 Alpha Stock Images

The findings of a new study indicate erectile dysfunction and inflammation could be prevented by blocking the effect of endothelin-1, which is a potent vasoconstrictor peptide and regulator of blood flow. A research team from Aarhus University in Denmark will present its findings virtually October 4–7 at the Seventeenth International Conference on Endothelin (ET-17), hosted and organized by the American Physiological Society (APS).

There is a strong, established tie between and erectile dysfunction, which is the inability to get and keep an erection for sex. Approximately half of all men with erectile dysfunction have a "robust risk for ," according to study author Rafael Fais, Ph.D., of National Jewish Health in Denver.

Endothelin-1, also referred to as downstream signal pathways, is released from the inner cell layer of blood vessels. It is closely associated with erectile dysfunction and inflammation because it can increase blood pressure. In this study, conducted using a , Fais blocked endothelin-1 by using an endothelial type A and B receptor antagonist called bosentan. Bosentan was injected directly into the cavernosal tissue of the penis, confirming the role of endothelin-1 in erectile dysfunction.

The findings suggest that endothelin-1 could play a significant role in reducing erectile dysfunction and inflammation. Fais hopes this study will lead to newer medications to treat and heart problems. Another goal is to increase a couple's quality of life by improving their sexual relationship.

Citation: Erectile dysfunction could be prevented by blocking endothelin-1 (2021, October 4) retrieved 21 February 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

The global prevalence of erectile dysfunction


Feedback to editors