Alzheimer's test provides much needed answers to patients and their families

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Over half a million Canadians are currently living with Alzheimer's disease or a related form of dementia, and with a rapidly aging population, that number is projected to double by 2031. Now, a new test will help patients find the answers they are seeking and assist their families in planning in the face of an Alzheimer's diagnosis.

"This is an urgent and rapidly growing health care issue," says Dr. Mari DeMarco, a Clinical Chemist at St. Paul's Hospital and a Clinical Associate Professor at the University of British Columbia in Vancouver, Canada. Her team developed a key component of the Alzheimer's disease test, and worked with individuals with lived experience with dementia, along with and other partners, to implement a comprehensive diagnostic testing strategy through its IMPACT-AD project, funded in part by Brain Canada. "The Alzheimer's disease biomarker test, which we have now made available to all Canadians, can help doctors accurately diagnose the disease even when only mild symptoms are present. Through the IMPACT-AD project, our aim was to gain a better understanding of how this testing impacts personal and medical decision making, and ."

The goal of IMPACT-AD is to inform positive change in the Canadian health care system to improve care and support for individuals living with Alzheimer's disease, and their families, according to DeMarco.

Who can take the test?

The test for Alzheimer's disease biomarkers through this program can only be ordered by a doctor specializing in dementia care. The doctor may recommend testing in individuals experiencing mild to moderate symptoms associated with Alzheimer's disease. Measuring changes in these biomarkers in the , the fluid surrounding the brain and spinal cord, helps doctors identify whether the cause of the symptoms may be due to Alzheimer's disease, and if the symptoms are likely to worsen over time.

With input from patients, their families, and their doctors, DeMarco and her colleagues are working to address barriers to uptake and use in the Canadian healthcare system.

How can the test help people experiencing memory loss and declining brain health?

Early and accurate diagnosis of Alzheimer's disease is critical because timely access to care and community services has the potential to lead to more effective treatment and improve quality of life. Current approaches for diagnosis rely on imaging tests and observation of the signs and symptoms of the disease. Adding the measure of proteins found in cerebrospinal fluid (biomarkers) has been shown to help correctly identify the and predict those with mild symptoms that are likely to progress to dementia.

The research appeared last year in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.

More information: Mari L. DeMarco et al, An automated clinical mass spectrometric method for identification and quantification of variant and wild‐type amyloid‐β 1‐40 and 1‐42 peptides in CSF, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2020). DOI: 10.1002/dad2.12036

Provided by Brain Canada Foundation
Citation: Alzheimer's test provides much needed answers to patients and their families (2021, December 15) retrieved 28 September 2023 from
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