COVID-19 spread undetected in US, Europe earlier than believed: study

COVID-19 spread undetected in US, Europe earlier than believed
Fig. 1: Early picture of the COVID-19 outbreak in Europe and the USA. a, Timelines of the daily reported and confirmed cases of COVID-19 in Europe (left) and the USA (right). BEL, Belgium; ESP, Spain; EU, European Union; FIN, Finland; FRA, France; GER, Germany; ITA, Italy; SWE; Sweden. b, Model-based estimates for the daily number of new infections in Europe (left) and the USA (right). The model estimates reported are the median values with the IQR obtained with an ABC calibration method using n = 200,000 independent model realizations. The inset plots compare the weekly incidence of reported cases with the median, weekly incidence of infections estimated by the model for the week of 8–14 March 2020 for the contiguous US states and European countries that reported at least one case (Europe, n = 30; USA, n = 48). Circle size corresponds to the population size of each state and country. The correlations were calculated using the Pearson correlation coefficient with a two-sided P value (Europe: ρ = 0.80, P < 0.001; USA: ρ = 0.79, P < 0.001). c, The probability that a city in Europe (left) and the USA (right) had generated at least 100 cumulative infections by 21 February 2020. Colour and circle size are proportional to the probability. Credit: DOI: 10.1038/s41586-021-04130-w

Local COVID-19 transmission was underway in California, New York, Florida and Texas well before the first reported U.S. case in Washington state on Jan. 20, 2020, according to a new study published in Nature, which indicates the virus spread much earlier and faster in the United States and Europe than previously thought.

The authors, an international team of infectious disease transmission experts, including Ira Longini, Ph.D., a biostatistics professor at the University of Florida College of Public Health and Health Professions and College of Medicine, conclude that the narrowness of the initial COVID-19 testing criteria, along with limited surveillance and testing availability, allowed the virus to circulate undetected for weeks. Community transmission was likely in several areas in Europe and the U.S. by December 2019 and January 2020, they write, and by early March, only 1 to 3 in 100 infections were detected by surveillance systems.

Reconstructing the early unnoticed spread of COVID-19 isn't just an interesting academic exercise, Longini said, it offers important insights to help countries prepare for future outbreaks of COVID-19 variants, such as omicron, or emerging infectious disease threats.

"Our model makes it possible to quickly project the size and path of an emerging epidemic much sooner than one would think," said Longini, a member of UF's Emerging Pathogens Institute. "With that information, you can implement epidemiologic interventions, such as surveillance and containment, in order to mitigate transmission on a local scale."

The team used a known as the Global Epidemic and Mobility project, or GLEAM, to track the first wave of COVID-19 in the U.S. and Europe. GLEAM separates the world into 3,200 subpopulations centered around transportation hubs in 200 cities to model possible epidemic scenarios, and is calibrated to real-world data on factors such as airline and ground transportation traffic flows, population demographics, disease dynamics, behaviors and the timing of interventions, including lockdowns.

The scientists used GLEAM early in the pandemic to analyze the spread of COVID-19 in China and concluded that travel restrictions from Wuhan may have only delayed the spread of the virus to mainland China by a few days. Findings from the new study reinforce the limits of in stopping the spread of infectious disease.

"Travel bans don't work; they're always too late," Longini said. "By the time a country implements a ban the disease is already spreading in that country. This is probably currently true for the COVID-19 omicron variant of concern, which is being found in many locations outside of Southern Africa."

What does work early in an outbreak, Longini said, is good surveillance and rapidly putting containment measures in place. In the case of COVID-19, for example, the illness has some distinct features, such as loss of taste and smell, and data monitoring on reported symptoms could have helped public health officials pinpoint areas of local transmission. Next, the use of polymerase chain reaction, or PCR, tests as soon as they are available, along with non-pharmaceutical interventions, such as mask-wearing, physical distancing, potential lockdowns and isolating cases and quarantining close contacts, can dramatically decrease transmission.

"That can be done with just basic shoe leather epidemiology and good infectious disease surveillance," Longini said. "But you have to know where to look and where to implement it. We have demonstrated that it is analytically possible to forecast early spread with the right tools. We have developed the model and methods to do that so next time we can project forward and use that information to coordinate early control strategies before we have treatments and vaccines."

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More information: Jessica T. Davis et al, Cryptic transmission of SARS-CoV-2 and the first COVID-19 wave, Nature (2021). DOI: 10.1038/s41586-021-04130-w
Journal information: Nature

Citation: COVID-19 spread undetected in US, Europe earlier than believed: study (2021, December 8) retrieved 21 January 2022 from
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