Topical tapinarof reduces severity of plaque psoriasis

Topical tapinarof reduces severity of plaque psoriasis

(HealthDay)—For adults with plaque psoriasis, tapinarof cream is better than vehicle control for reducing disease severity, according to a study published in the Dec. 9 issue of the New England Journal of Medicine.

Mark G. Lebwohl, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted two identical phase 3 randomized trials of tapinarof in adults with mild-to-. Adults with a baseline Physician's Global Assessment (PGA) score of 2 (mild) to 4 (severe) and 3 to 20 percent of total body-surface area affected were randomly assigned in a 2:1 ratio to 12 weeks of tapinarof 1 percent or vehicle cream once daily. A total of 510 and 515 patients were enrolled in trials 1 and 2, respectively.

The researchers found that a PGA response occurred in 35.4 and 6.0 percent of patients in the tapinarof and placebo groups, respectively, in trial 1 and in 40.2 and 6.3 percent of patients, respectively, in trial 2. For secondary end points and patient-reported outcomes, the results were mainly in the same direction. Folliculitis, nasopharyngitis, , headache, upper respiratory tract infection, and pruritus were adverse events associated with tapinarof cream.

"In these 12-week , the topical aryl hydrocarbon receptor-modulating agent tapinarof was superior to vehicle in reducing the manifestations of psoriasis but was associated with local adverse events and headache," the authors write.

The study was funded by Dermavant Sciences, the manufacturer of tapinarof.

Explore further

Researchers discover that topical treatment improves chronic plaque psoriasis

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Journal information: New England Journal of Medicine

Copyright © 2021 HealthDay. All rights reserved.

Citation: Topical tapinarof reduces severity of plaque psoriasis (2021, December 9) retrieved 25 May 2022 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors