Depression linked to more severe dry eye disease

Depression linked to more severe dry eye disease

Depression is associated with more severe dry eye disease (DED) symptoms and overall signs, according to a study published online March 10 in JAMA Ophthalmology.

Yi Zhou, from the University of Pennsylvania in Philadelphia, and colleagues examined the association between depression and the severity of DED symptoms and signs, including inflammatory markers in a secondary cross-sectional and longitudinal analysis of data from the Dry Eye Assessment and Management study, involving with moderate-to- and signs of DED. A total of 535 patients from 27 ophthalmology and optometry centers were followed for one year.

The researchers found that patients who screened positive for depression had worse DED symptoms based on the Ocular Surface Disease Index (OSDI) and Brief Ocular Discomfort Index and composite DED sign score. Worse depression, as indicated by a lower Mental Component Summary score on the 36-item Short Form Health Survey, was associated with a higher OSDI score (worse symptoms) at baseline, six months, and 12 months. No difference was seen in by depression status.

"Identifying and considering treatment, including systemic medications, may be useful in managing patients with DED," the authors write. "Patients with more severe DED concerns or sign measurements may benefit from comorbid psychiatric screening."


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More information: Yi Zhou et al, Association Between Depression and Severity of Dry Eye Symptoms, Signs, and Inflammatory Markers in the DREAM Study, JAMA Ophthalmology (2022). DOI: 10.1001/jamaophthalmol.2022.0140

Anat Galor, How Depression Might Relate to Dry Eye Disease, JAMA Ophthalmology (2022). DOI: 10.1001/jamaophthalmol.2022.0146

Several authors disclosed financial ties to the biopharmaceutical industry.

Journal information: JAMA Ophthalmology

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