Excessive gestational weight gain increases long-term maternal cardiovascular risk

pregnant
Credit: CC0 Public Domain

Pregnant women with excessive gestational weight gain had a higher cardiovascular risk profile in midlife, according to a new study published in the Journal of Women's Health.

Franya Hutchins, Ph.D., from the University of Pittsburgh Graduate School of Public Health, and coauthors used two main measures to determine a woman's cardiovascular disease risk: the atherosclerotic cardiovascular disease (ASCVD) risk score and a measure of the C-reactive protein (CRP), an inflammatory biomarker. The investigators measured these variables at baseline and at 10 follow-up visits, for a total of 20 years of follow-up.

Having a history of excessive gestational weight gain was associated with a 29.6% higher ASCVD risk score at baseline. "In the model including confounders and midlife , excessive gestational weight gain remained associated with a 9.1% higher ASCVD score," stated the investigators. Excessive gestational weight gain was associated with an 89.2% higher baseline CRP level. With the addition of cofounders and midlife abdominal obesity, excessive gestational weight gain remained associated with a 31.5% higher mean CRP.

"In this group of women, a history of excessive gestational weight gain was associated with a small but statistically significant higher ASCVD score and a moderate, statistically significant higher mean CRP level into midlife," says Journal of Women's Health Editor-in-Chief Susan G. Kornstein, MD, Executive Director of the Virginia Commonwealth University Institute for Women's Health, Richmond, VA.


Explore further

Cumulative overweight pregnancies increase risk of maternal midlife obesity

More information: Franya Hutchins et al, Excessive Gestational Weight Gain and Long-Term Maternal Cardiovascular Risk Profile: The Study of Women's Health Across the Nation, Journal of Women's Health (2022). DOI: 10.1089/jwh.2021.0449
Journal information: Journal of Women's Health

Citation: Excessive gestational weight gain increases long-term maternal cardiovascular risk (2022, May 16) retrieved 3 July 2022 from https://medicalxpress.com/news/2022-05-excessive-gestational-weight-gain-long-term.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
6 shares

Feedback to editors