Microrobot device removes brain hemorrhages due to strokes or aneurysms

Microrobot device removes brain hemorrhages due to strokes or aneurysms
Design and fabrication of a self-clearing ventricular catheter. a) Polyimide spin coat and curing on single-crystal silicon (Si) wafer with silicon dioxide (SiO2) release layer. b) Evaporation of Cr etching mask and define photoresist for actuator outline. c) Wet etch of chromium (Cr) and dry etch of polyimide. d) Removal of Cr and evaporation of gold (Au) as a conduction layer. e) Application of photoresist and nickel (Ni) electroplating. f) Removal of photoresist and remaining Au layer. g) Optical images of fabricated magnetic actuators of straight type (top) and serpentine type (middle). Scale bars = 325 μm. A catheter with an integrated actuator (bottom). Scale bar = 1 mm. h A typical motion of actuation in deionized (DI) water for one actuation period. Credit: Nature Communications (2022). DOI: 10.1038/s41467-022-28101-5

A new treatment for strokes caused by bleeding in the brain that uses a magnetically controlled microrobot-enabled self-clearing catheter has been shown to be 86% effective in animal models, according to a paper published in Nature Communications.

Hyowon "Hugh" Lee, a Purdue University associate professor from the Weldon School of Biomedical Engineering, created the magnetically controlled microdevice that removes blood accumulating in the brain during a . The innovation was tested on porcine models of hemorrhage in collaboration with neurosurgeons Dr. Timothy Bentley from Purdue's College of Veterinary Medicine and Dr. Albert Lee from Goodman Campbell Brain and Spine in Carmel, Indiana.

The microrobots successfully removed the blood in six of the seven animals in the treatment animal model.

"This innovation is a real advance in the care of strokes, which are notoriously difficult to treat," Hugh Lee said.

The current gold standard to treat strokes is a blood thinner called tissue plasminogen activator, which cannot be used for some hemorrhagic strokes.

"Patients with hemorrhages have a mortality rate of up to 50%," Albert Lee said. "Currently there is no great therapeutic solution for intraventricular hemorrhage. The only other option is clot-dissolving drugs that have undesirable risks."

The full range of motion of a magnetically controlled microdevice invented by Purdue University associate professor Hyowon “Hugh” Lee to remove blood accumulating in the brain during a stroke. Credit: Hyowon “Hugh” Lee
A magnetically controlled microdevice invented by Purdue University associate professor Hyowon “Hugh” Lee removes a clot from the brain. Credit: Hyowon “Hugh” Lee

Hugh Lee's innovation, which was developed with a former graduate student, Qi Yang, can be remotely activated using externally applied magnetic fields.

"There is no need for an implanted power source or complicated integrated circuit," Hugh Lee said. "As you change the direction of the , the microdevice moves like a compass needle with a magnet nearby. They can be part of an implantable shunt system or a part of extra ventricular drainage systems."

Hugh Lee disclosed the to the Purdue Research Foundation Office of Technology Commercialization, which has filed for a patent on the intellectual property. The next step to further develop the device is to receive approval from the U.S. Food and Drug Administration for a first-in-human study.

More information: Qi Yang et al, Application of magnetically actuated self-clearing catheter for rapid in situ blood clot clearance in hemorrhagic stroke treatment, Nature Communications (2022). DOI: 10.1038/s41467-022-28101-5

Journal information: Nature Communications
Provided by Purdue University
Citation: Microrobot device removes brain hemorrhages due to strokes or aneurysms (2022, June 15) retrieved 18 July 2024 from https://medicalxpress.com/news/2022-06-microrobot-device-brain-hemorrhages-due.html
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