New type of antibiotic could fight tough-to-treat UTIs

New type of antibiotic could fight tough-to-treat UTIs

The world desperately needs new antibiotics to fight infection as bacteria become resistant to existing options.

GSK has developed a to treat (UTIs) that appears to be so effective the pharmaceutical company stopped testing early on the recommendation of independent monitors and plans to submit data to the U.S. Food and Drug Administration soon, CNN reported.

The new antibiotic, called gepotidacin, is the first developed in more than 20 years to treat UTIs. It works by blocking enzymes the bacteria need to start multiplying in the body. UTIs happen to people of all ages, but are common and especially dangerous for frail, .

The new treatment appears to work at least as well as nitrofurantoin, which is the current front-line UTI medication, CNN reported.

"Stopping studies in such circumstances is a pretty rare occurrence in the industry. So it's something I'm absolutely delighted about, both from and from a company perspective," GSK's chief scientific officer Tony Wood said during a call with reporters Thursday.

The company plans to publish its findings in a .

Gepotidacin was developed in partnership with the U.S. government, as one of 19 projects aimed at fighting antimicrobial resistance. The Biomedical Advanced Research and Development Authority is funding the work.

"It's definitely a big deal," said Dr. Cindy Liu, chief medical officer at the Antibiotic Resistance Action Center at George Washington University, in Washington, D.C. Many antibiotics don't make it from the first to the second phase of human trials and others drop out because funding falls short, she said.

"So this is something that we've been dealing with, at the same time when there are increasing numbers of infections that are harder and harder to treat with the drugs that we do have," Liu said.

In addition, Liu said that some companies still drop out even after gaining approval if their drugs aren't profitable, CNN reported.

GSK's announcement follows news of a separate study that found an experimental antibiotic combo outperformed an established regimen in treating stubborn UTIs. Nearly eight in 10 patients treated with cefepime/enmetazobactam had their completely clear, compared with about six in 10 who received a .

A 2021 World Health Organization report warned about the lack of antibiotic development despite the threat of antibiotic resistance, which claims more than 1 million lives each year.

More information: The U.S. Centers for Disease Control and Prevention has more on antimicrobial resistance.

Copyright © 2022 HealthDay. All rights reserved.

Citation: New type of antibiotic could fight tough-to-treat UTIs (2022, November 4) retrieved 21 May 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

New drug is found effective for treating complicated urinary tract infections


Feedback to editors