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Researchers suggest that human aging is the end-product of our developmental program

Researchers suggest that human aging is the end-product of our developmental program
Aging as the result of software design flaws. The developmental software program is a set of instructions or interconnected subroutines with numerous inputs and outputs that trigger a complicated cascade of events that drive growth and development. Because this software program is optimized for reproduction, however, it fails to deactivate a subset of its subroutines which are beneficial during development (blue shading) but then become detrimental later in life (red shading). With age, such subroutines could gradually lead to the inappropriate activation or inactivation of genes, pathways, and processes that drive aging phenotypes. The running of the developmental software program is reflected in the epigenome, the software’s data area. Human life course drawing by Alice C Magalhaes. Epigenome figure created with Credit: Genome Biology (2023). DOI: 10.1186/s13059-023-02888-y

A new study published in Genome Biology has challenged the traditional view that aging is a result of the accumulation of damage to the body's hardware, such as the molecular damage to cells caused by oxidative stress. Instead, the study suggests that aging is primarily a result of design flaws in the software of our bodies—the DNA code that orchestrates the development of a single cell into an adult organism.

The study considers the question, why does aging happen uniformly when work on the assumption that we accumulate "damage" randomly? If we imagine as the product of a sort of computer program encoded in the DNA, the paper suggests that aging is not an accumulation of damage to the hardware, but a process driven by flaws in the software, a radical departure from damage-based theories that until now have prevailed in aging research.

The study's authors propose a model of aging as the outcome of the developmental software program and reflected in shifting cellular information states throughout the . The model explains why closely related species age at radically different rates, and it explains the major genetic, dietary, and pharmacological manipulations of aging in animals.

Viewing aging as an information problem, rather than a result of damage, has important implications for the development of interventions to slow or reverse the . Traditional anti-aging interventions targeting damage, such as those aimed at reducing or telomere shortening, may have limited success if aging is primarily a result of software programs.

According to the study's authors, aging therapies will only be effective if they target the software of the body rather than the hardware. This new perspective has important implications for our understanding of aging and the development of interventions to promote healthy aging.

Professor João Pedro Magalhães from the University of Birmingham who led the research, said, "Our model is controversial as it challenges the prevailing view of aging as a result of random damage to the body's hardware. Instead, we suggest that aging is an information problem that is driven by design flaws in our body's software. As the developmental program runs early in life, it is beneficial, but its runs later in life become detrimental and drive tissue degeneration and aging phenotypes."

More information: João Pedro de Magalhães, Ageing as a software design flaw, Genome Biology (2023). DOI: 10.1186/s13059-023-02888-y

Journal information: Genome Biology

Citation: Researchers suggest that human aging is the end-product of our developmental program (2023, March 28) retrieved 4 June 2023 from
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