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Study establishes link between wound fibroblasts and cancer-associated fibroblasts

Phase-specific signatures of wound fibroblasts and matrix patterns
Conceptual summary: During wound healing, sequential healing phases return the injured tissue to homeostasis. As a "wound that fails to heal", cancer stalls in the early phases of repair, with cancer cells and stromal cells continually releasing cytokines, growth factors and extracellular matrix (ECM). Fibroblast functions of the early healing phase become hyper-activated in "early-wound" cancer-associated fibroblast (CAF) subtypes close to the tumor margins, contributing to the accumulation of pro-tumorigenic collagen-forming and contractile CAFs that exacerbate the fibrotic ECM microenvironment. Further away from the tumor margins, there is a gradient toward the normalization of the tumor-adjacent microenvironment mediated by "late-wound" CAF subtypes that deposit an elastin-enriched ECM network similar to that found in a resolving wound. Credit: ETH Zurich

A Matrix Biology paper by the Werner group (IMHS) shows how wound healing gene expression signatures are expressed in tumors and can be used to predict cancer outcome. The paper establishes a functional link between wound fibroblasts and cancer-associated fibroblasts through expression of certain extracellular matrix genes.

Wound healing and cancer formation share many cellular and molecular parallels, but the two have not been systematically compared. Using transcriptomics at the whole tissue, single-cell and spatial levels, Wietecha et al. profiled across time and compared them to tumors. They discovered prognostic healing expressed in various cancers that link wound fibroblasts to a common feature of malignant tumors mediated by cancer-associated fibroblasts—fibrosis.

The healing signatures from the early and late wounds enriched for divergent extracellular matrix repertoires that were visualized in primary melanoma biopsies and predicted cancer survival and recurrence. The authors further showed how the early wound and cancer-associated fibroblast subtype is activated by the RUNX2 transcription factor. The results pave the way for the development of innovative healing-based diagnostic and prognostic tools to better identify spread and more accurately predict cancer outcome.

More information: Mateusz S. Wietecha et al, Phase-specific signatures of wound fibroblasts and matrix patterns define cancer-associated fibroblast subtypes, Matrix Biology (2023). DOI: 10.1016/j.matbio.2023.03.003

Provided by ETH Zurich
Citation: Study establishes link between wound fibroblasts and cancer-associated fibroblasts (2023, March 27) retrieved 14 July 2024 from
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