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Mapping the genetic history of French Canadians through space and time

Mapping the genetic history of French Canadians through space and time
The ice bridge on the St. Lawrence river between Québec and Lévis, Quebec, Canada, in 1892. Credit: Bibliothèque et Archives nationales du Québec

Though we all share common ancestors ranging from a few generations to hundreds of thousands of years, genealogies that relate all of us are often forgotten over time. A new McGill University-led study published in Science is now providing insight into the complex relationship between human migration and genetic variation, using a unique genealogical dataset of over five million records spanning 400 years to unravel the genetic structure of French Canadian populations.

The team, including researchers from Université du Québec à Chicoutimi and the Big Data Institute at the University of Oxford, developed a new method to simulate genomes based on a population scale genealogy dating back to the arrival of the first French settlers. By comparing the simulations to real genetic data, they were able to prove that the genetic structure of this population was encoded within its genealogy.

"It is the first genetic study, in any worldwide population, that incorporates genealogical records to provide a strikingly accurate map of genetic relatedness at the population scale," explains Simon Gravel, Assistant Professor in McGill's Department Human Genetics and one of the study's authors.

How rivers and mountains influenced population structure

The dataset was used in part to investigate how certain and landscapes have influenced the genomes of French Canadians today. The study highlights the relationship between river networks and genetic similarity, as European colonial history was marked by a rapid expansion of borders along the banks of the St. Lawrence River and its tributaries.

"This study tells the genetic story of French Canadians, showing that their population structure today is not a result of ancestral French population structure, but rather one that has been shaped by events in North America over the past four centuries," says Prof. Gravel. "We were even able to tie a meteor impact crater in the region of Charlevoix, to the appearance of a founder effect observed in the Saguenay-Lac-Saint-Jean region."

Using ancestral data to help identify genetic diseases and treatments

By tracing the ancestry of millions of individuals over space and time, the study bridges the gaps between family pedigrees and continental structure, providing valuable insights into the complex tapestry of human genetic history. "Beyond mapping the rich genetic history of French Canadians, the findings have significant implications for understanding the impact of migration on and the broader history of humanity," adds Prof. Gravel.

The researchers are hoping that the large, freely-available simulated dataset with realistic and mating patterns will help improve genetic risk prediction, historical inference, and genealogical inference, which could have potential implications for identifying and improving medical treatments.

More information: Luke Anderson-Trocmé et al, On the genes, genealogies, and geographies of Quebec, Science (2023). DOI: 10.1126/science.add5300

A French version of the study is available here.

Journal information: Science

Provided by McGill University
Citation: Mapping the genetic history of French Canadians through space and time (2023, May 25) retrieved 5 June 2023 from
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