This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


peer-reviewed publication

reputable news agency


Genetic links seen for HDL cholesterol, systolic BP with Alzheimer's disease

Credit: Pixabay/CC0 Public Domain

Genetically determined high-density lipoprotein (HDL) cholesterol and high systolic blood pressure are associated with increased odds of Alzheimer's disease (AD), according to a study published online May 17 in JAMA Network Open.

Jiao Luo, M.D., Ph.D., from Copenhagen University Hospital-Rigshospitalet in Denmark, and colleagues conducted a genetic association study using two-sample univariable and multivariable Mendelian randomization to examine potentially causal aspects of modifiable risk factors for AD. Independent genetic variants associated with modifiable risk factors were selected as instrumental variables. Outcome data were obtained from the European Alzheimer & Dementia Biobank (EADB).

The EADB-diagnosed cohort included 39,106 and 401,577 participants with clinically diagnosed AD and controls without AD, respectively. The researchers found that the odds of AD were increased in association with genetically determined HDL cholesterol concentrations (odds ratio, 1.10 per one standard deviation [one-SD] increase).

After adjusting for , genetically determined high was associated with an increased risk for AD (odds ratio, 1.22 per 10-mm Hg increase). In a second analysis to minimize bias due to sample overlap, the odds for AD were similar for HDL cholesterol and systolic blood pressure (odds ratios, 1.08 per one-SD unit increase and 1.23 per 10-mm Hg increase, respectively).

"These findings may inspire new drug targeting and improved early dementia prevention," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

More information: et al, Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease, JAMA Network Open (2023). DOI: 10.1001/jamanetworkopen.2023.13734

Journal information: JAMA Network Open

Copyright © 2023 HealthDay. All rights reserved.

Citation: Genetic links seen for HDL cholesterol, systolic BP with Alzheimer's disease (2023, May 17) retrieved 23 July 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Causal link identified between bipolar disorder, IBD


Feedback to editors